Literature DB >> 25591050

One step closer to targeting RAS.

Chao Yan1, Dan Theodorescu.   

Abstract

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Year:  2015        PMID： 25591050      PMCID： PMC4614980          DOI： 10.1080/15384101.2015.1006534

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


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  5 in total

1.  Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.

Authors:  Till Maurer; Lindsay S Garrenton; Angela Oh; Keith Pitts; Daniel J Anderson; Nicholas J Skelton; Benjamin P Fauber; Borlan Pan; Shiva Malek; David Stokoe; Mary J C Ludlam; Krista K Bowman; Jiansheng Wu; Anthony M Giannetti; Melissa A Starovasnik; Ira Mellman; Peter K Jackson; Joachim Rudolph; Weiru Wang; Guowei Fang
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-19       Impact factor: 11.205

Review 2.  Strategies for the selective regulation of kinases with allosteric modulators: exploiting exclusive structural features.

Authors:  Zhizhou Fang; Christian Grütter; Daniel Rauh
Journal:  ACS Chem Biol       Date:  2012-12-31       Impact factor: 5.100

3.  Discovery and characterization of small molecules that target the GTPase Ral.

Authors:  Chao Yan; Degang Liu; Liwei Li; Michael F Wempe; Sunny Guin; May Khanna; Jeremy Meier; Brenton Hoffman; Charles Owens; Christina L Wysoczynski; Matthew D Nitz; William E Knabe; Mansoor Ahmed; David L Brautigan; Bryce M Paschal; Martin A Schwartz; David N M Jones; David Ross; Samy O Meroueh; Dan Theodorescu
Journal:  Nature       Date:  2014-09-14       Impact factor: 49.962

4.  In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.

Authors:  Fumi Shima; Yoko Yoshikawa; Min Ye; Mitsugu Araki; Shigeyuki Matsumoto; Jingling Liao; Lizhi Hu; Takeshi Sugimoto; Yuichi Ijiri; Azusa Takeda; Yuko Nishiyama; Chie Sato; Shin Muraoka; Atsuo Tamura; Tsutomu Osoda; Ken-ichiro Tsuda; Tomoya Miyakawa; Hiroaki Fukunishi; Jiro Shimada; Takashi Kumasaka; Masaki Yamamoto; Tohru Kataoka
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-29       Impact factor: 11.205

5.  Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.

Authors:  Qi Sun; Jason P Burke; Jason Phan; Michael C Burns; Edward T Olejniczak; Alex G Waterson; Taekyu Lee; Olivia W Rossanese; Stephen W Fesik
Journal:  Angew Chem Int Ed Engl       Date:  2012-05-08       Impact factor: 15.336
  5 in total
  1 in total

Review 1.  The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production.

Authors:  Schuyler A Chambers; Jenna M DeSousa; Eric D Huseman; Steven D Townsend
Journal:  ACS Chem Neurosci       Date:  2018-02-01       Impact factor: 4.418
  1 in total

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