| Literature DB >> 2559062 |
S M Moerlein1, J W Brodack, B A Siegel, M J Welch.
Abstract
Radiopharmaceutical solutions of 2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG) prepared via an aminopolyether-supported nucleophilic-substitution mechanism were analyzed for contaminant 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo-[8,8,8]-hexacosane (Kryptofix 2.2.2). Washing the C18-immobilized [18F]fluoro-tetraacetylated intermediate with 10 mL 0.1 M HCl was found to remove impurity Kryptofix 2.2.2 from the final product. Inclusion of this synthetic step allowed the robotic production of drug-quality 2-[18F]FDG in 52-56% radiochemical yield within 75 min. A thin-layer chromatographic system for the clinical screening of the radiochemical and chemical purity of this radiopharmaceutical is described.Entities:
Mesh：
Substances：
Year: 1989 PMID： 2559062 DOI： 10.1016/0883-2889(89)90090-7
Source DB: PubMed Journal: Int J Rad Appl Instrum A ISSN： 0883-2889