Literature DB >> 2559038

Influence of Ly146032 on chemotaxis, chemiluminescence of PMN and lymphocyte transformation in vitro.

S Schubert1, U Ullmann.   

Abstract

The influence of Ly146032, a new acidic lipopeptide, on chemotaxis, luminol-dependent chemiluminescence of human polymorphonuclear leukocytes (PMN) and phythemagglutinin induced lymphocyte transformation of murine cells was investigated. At therapeutic range there was no remarkable effect on the parameters tested. Incubation with more than 20 mg/l Ly146032 was followed by depression of chemiluminescence, whilst transformation of maximally PHA stimulated lymphocytes was suppressed by more than 32 mg/l Ly146032.

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Year:  1989        PMID： 2559038     DOI： 10.1007/BF01645548

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


  13 in total

1.  Comparative in-vitro activity of LY146032 and eight other antibiotics against gram-positive bacteria isolated from children.

Authors:  M W Kline; E O Mason; S L Kaplan; L B Lamberth; G S Johnson
Journal:  J Antimicrob Chemother       Date:  1987-08       Impact factor: 5.790

2.  Comparative in-vitro activity of LY146032 a new peptolide, with vancomycin and eight other agents against gram-positive organisms.

Authors:  C A Benson; F Beaudette; G Trenholm
Journal:  J Antimicrob Chemother       Date:  1987-08       Impact factor: 5.790

3.  LY146032: activity and resistance development in vitro.

Authors:  R P Mouton; S L Mulders
Journal:  J Antimicrob Chemother       Date:  1987-10       Impact factor: 5.790

4.  A modified method for chemotaxis under agarose.

Authors:  D E Chenoweth; J G Rowe; T E Hugli
Journal:  J Immunol Methods       Date:  1979       Impact factor: 2.303

5.  Influence of various antimicrobial agents on the chemiluminescence of phagocytosing human granulocytes.

Authors:  D Duncker; U Ullmann
Journal:  Chemotherapy       Date:  1986       Impact factor: 2.544

6.  Influence of LY146032 on human polymorphonuclear leucocytes in vitro.

Authors:  P Van der Auwera; G Petrikkos; T Matsumoto; M Husson
Journal:  J Antimicrob Chemother       Date:  1988-01       Impact factor: 5.790

7.  Comparison of the investigational drug, LY146032, with vancomycin in experimental pneumonia due to methicillin-resistant Staphylococcus aureus.

Authors:  P A Kephart; A L Esposito
Journal:  J Antimicrob Chemother       Date:  1988-01       Impact factor: 5.790

8.  In vitro activity and mechanism of action of A21978C1, a novel cyclic lipopeptide antibiotic.

Authors:  G M Eliopoulos; C Thauvin; B Gerson; R C Moellering
Journal:  Antimicrob Agents Chemother       Date:  1985-03       Impact factor: 5.191

9.  Antibiotics and granulocytes. Direct and indirect effects on granulocyte chemotaxis.

Authors:  J A Belsheim; G H Gnarpe
Journal:  Acta Pathol Microbiol Scand C       Date:  1981-08

10.  Effect of imipenem (N-formimidoyl-thienamycin) on the in-vitro lymphocyte proliferation.

Authors:  J C Petit; B Burghoffer; G Richard; G L Daguet
Journal:  J Antimicrob Chemother       Date:  1987-12       Impact factor: 5.790
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  1 in total

Review 1.  Daptomycin.

Authors:  Caroline Fenton; Gillian M Keating; Monique P Curran
Journal:  Drugs       Date:  2004       Impact factor: 9.546
  1 in total

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