Literature DB >> 25589647

Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.

Kalani Halemano1, Bradley S Barrett2, Karl J Heilman2, Thomas E Morrison3, Mario L Santiago4.   

Abstract

Antiretroviral neutralizing antibody (NAb) responses are often evaluated in the absence of Fc-dependent immune effectors. In murine Friend retrovirus infection, Apobec3/Rfv3 promotes a potent polyclonal NAb response. Here, we show that the Apobec3/Rfv3-dependent NAb response correlated with virus-specific IgG2 titers and that the in vivo neutralization potency of Apobec3/Rfv3-resistant antisera was dependent on activating Fcγ receptors but not complement. The data strengthen retroviral vaccine strategies aimed at eliciting NAbs that activate specific Fcγ receptors.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25589647      PMCID： PMC4403405          DOI： 10.1128/JVI.03399-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  Fc receptor but not complement binding is important in antibody protection against HIV.

Authors:  Ann J Hessell; Lars Hangartner; Meredith Hunter; Carin E G Havenith; Frank J Beurskens; Joost M Bakker; Caroline M S Lanigan; Gary Landucci; Donald N Forthal; Paul W H I Parren; Preston A Marx; Dennis R Burton
Journal:  Nature       Date:  2007-09-06       Impact factor: 49.962

2.  Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.

Authors:  B Chesebro; K Wehrly; D Doig; J Nishio
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

3.  FcR gamma chain deletion results in pleiotrophic effector cell defects.

Authors:  T Takai; M Li; D Sylvestre; R Clynes; J V Ravetch
Journal:  Cell       Date:  1994-02-11       Impact factor: 41.582

4.  Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in friend virus-infected mice.

Authors:  Sachiyo Tsuji-Kawahara; Tomomi Chikaishi; Eri Takeda; Maiko Kato; Saori Kinoshita; Eiji Kajiwara; Shiki Takamura; Masaaki Miyazawa
Journal:  J Virol       Date:  2010-04-07       Impact factor: 5.103

5.  Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.

Authors:  Mario L Santiago; Robert L Benitez; Mauricio Montano; Kim J Hasenkrug; Warner C Greene
Journal:  J Immunol       Date:  2010-06-21       Impact factor: 5.422

6.  Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection.

Authors:  Maiko Kato; Sachiyo Tsuji-Kawahara; Yuri Kawasaki; Saori Kinoshita; Tomomi Chikaishi; Shiki Takamura; Makoto Fujisawa; Akira Kawada; Masaaki Miyazawa
Journal:  J Virol       Date:  2014-11-05       Impact factor: 5.103

7.  Complement receptor 3 promotes severe ross river virus-induced disease.

Authors:  Thomas E Morrison; Jason D Simmons; Mark T Heise
Journal:  J Virol       Date:  2008-09-10       Impact factor: 5.103

8.  Use of monoclonal anti-gp70 antibodies to mimic the effects of the Rfv-3 gene in mice with Friend virus-induced leukemia.

Authors:  W J Britt; B Chesebro
Journal:  J Immunol       Date:  1983-05       Impact factor: 5.422

9.  Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.

Authors:  Mario L Santiago; Mauricio Montano; Robert Benitez; Ronald J Messer; Wes Yonemoto; Bruce Chesebro; Kim J Hasenkrug; Warner C Greene
Journal:  Science       Date:  2008-09-05       Impact factor: 47.728

10.  Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.

Authors:  D Doig; B Chesebro
Journal:  J Exp Med       Date:  1979-07-01       Impact factor: 14.307
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  8 in total

1.  SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide.

Authors:  BradleyS Barrett; David H Nguyen; Joella Xu; Kejun Guo; Shravida Shetty; Sean T Jones; Kaylee L Mickens; Caitlin Shepard; Axel Roers; Rayk Behrendt; Li Wu; Baek Kim; Mario L Santiago
Journal:  J Immunol       Date:  2021-12-10       Impact factor: 5.426

Review 2.  Tetherin/BST-2: Restriction Factor or Immunomodulator?

Authors:  Sam X Li; Bradley S Barrett; Kejun Guo; Mario L Santiago
Journal:  Curr HIV Res       Date:  2016       Impact factor: 1.581

3.  Filariae-Retrovirus Co-infection in Mice is Associated with Suppressed Virus-Specific IgG Immune Response and Higher Viral Loads.

Authors:  Kirsten Katrin Dietze; Ulf Dittmer; Daniel Karim Koudaimi; Simone Schimmer; Martina Reitz; Minka Breloer; Wiebke Hartmann
Journal:  PLoS Negl Trop Dis       Date:  2016-12-06

4.  Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction.

Authors:  Bradley S Barrett; Michael S Harper; Sean T Jones; Kejun Guo; Karl J Heilman; Ross M Kedl; Kim J Hasenkrug; Mario L Santiago
Journal:  Retrovirology       Date:  2017-04-17       Impact factor: 4.602

Review 5.  Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1.

Authors:  Marta Colomer-Lluch; Alba Ruiz; Arnaud Moris; Julia G Prado
Journal:  Front Immunol       Date:  2018-12-06       Impact factor: 7.561

Review 6.  Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity.

Authors:  Ulf Dittmer; Kathrin Sutter; George Kassiotis; Gennadiy Zelinskyy; Zoltán Bánki; Heribert Stoiber; Mario L Santiago; Kim J Hasenkrug
Journal:  FEMS Microbiol Rev       Date:  2019-09-01       Impact factor: 16.408

7.  Bone marrow stromal antigen 2 (BST-2) genetic variants influence expression levels and disease outcome in HIV-1 chronically infected patients.

Authors:  Hlelolwenkosi Mlimi; Kewreshini K Naidoo; Jenniffer Mabuka; Thumbi Ndung'u; Paradise Madlala
Journal:  Retrovirology       Date:  2022-01-26       Impact factor: 4.602

8.  Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.

Authors:  Sam X Li; Bradley S Barrett; Kejun Guo; George Kassiotis; Kim J Hasenkrug; Ulf Dittmer; Kathrin Gibbert; Mario L Santiago
Journal:  Sci Rep       Date:  2016-02-05       Impact factor: 4.379
  8 in total

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