Literature DB >> 25589638

On the stability of parainfluenza virus 5 F proteins.

Taylor A Poor1, Albert S Song1, Brett D Welch2, Christopher A Kors2, Theodore S Jardetzky3, Robert A Lamb4.   

Abstract

The crystal structure of the F protein (prefusion form) of the paramyxovirus parainfluenza virus 5 (PIV5) WR isolate was determined. We investigated the basis by which point mutations affect fusion in PIV5 isolates W3A and WR, which differ by two residues in the F ectodomain. The P22 stabilizing site acts through a local conformational change and a hydrophobic pocket interaction, whereas the S443 destabilizing site appears sensitive to both conformational effects and amino acid charge/polarity changes.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25589638      PMCID： PMC4337539          DOI： 10.1128/JVI.03221-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  16 in total

1.  Fusion protein of the paramyxovirus SV5: destabilizing and stabilizing mutants of fusion activation.

Authors:  R G Paterson; C J Russell; R A Lamb
Journal:  Virology       Date:  2000-04-25       Impact factor: 3.616

2.  Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy.

Authors:  Sarah A Connolly; George P Leser; Hsien-Shen Yin; Theodore S Jardetzky; Robert A Lamb
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-08       Impact factor: 11.205

3.  Role of a single amino acid at the amino terminus of the simian virus 5 F2 subunit in syncytium formation.

Authors:  M Ito; M Nishio; M Kawano; S Kusagawa; H Komada; Y Ito; M Tsurudome
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

4.  Mechanism for active membrane fusion triggering by morbillivirus attachment protein.

Authors:  Nadine Ader; Melinda Brindley; Mislay Avila; Claes Örvell; Branka Horvat; Georg Hiltensperger; Jürgen Schneider-Schaulies; Marc Vandevelde; Andreas Zurbriggen; Richard K Plemper; Philippe Plattet
Journal:  J Virol       Date:  2012-10-17       Impact factor: 5.103

5.  Fusion activation by a headless parainfluenza virus 5 hemagglutinin-neuraminidase stalk suggests a modular mechanism for triggering.

Authors:  Sayantan Bose; Aarohi Zokarkar; Brett D Welch; George P Leser; Theodore S Jardetzky; Robert A Lamb
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-04       Impact factor: 11.205

6.  A single amino acid change in the Newcastle disease virus fusion protein alters the requirement for HN protein in fusion.

Authors:  T A Sergel; L W McGinnes; T G Morrison
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

7.  Structure of the cleavage-activated prefusion form of the parainfluenza virus 5 fusion protein.

Authors:  Brett D Welch; Yuanyuan Liu; Christopher A Kors; George P Leser; Theodore S Jardetzky; Robert A Lamb
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-10       Impact factor: 11.205

8.  Biochemical, conformational, and immunogenic analysis of soluble trimeric forms of henipavirus fusion glycoproteins.

Authors:  Yee-Peng Chan; Min Lu; Somnath Dutta; Lianying Yan; Jennifer Barr; Michael Flora; Yan-Ru Feng; Kai Xu; Dimitar B Nikolov; Lin-Fa Wang; Georgios Skiniotis; Christopher C Broder
Journal:  J Virol       Date:  2012-08-22       Impact factor: 5.103

9.  Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) ectodomain.

Authors:  Brett D Welch; Ping Yuan; Sayantan Bose; Christopher A Kors; Robert A Lamb; Theodore S Jardetzky
Journal:  PLoS Pathog       Date:  2013-08-08       Impact factor: 6.823

10.  Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation.

Authors:  Hsien-Sheng Yin; Xiaolin Wen; Reay G Paterson; Robert A Lamb; Theodore S Jardetzky
Journal:  Nature       Date:  2006-01-05       Impact factor: 49.962
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  5 in total

1.  Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation.

Authors:  Ryan Abdella; Megha Aggarwal; Takashi Okura; Robert A Lamb; Yuan He
Journal:  Proc Natl Acad Sci U S A       Date:  2020-02-19       Impact factor: 11.205

2.  Flexibility of the Head-Stalk Linker Domain of Paramyxovirus HN Glycoprotein Is Essential for Triggering Virus Fusion.

Authors:  Emmanuel Adu-Gyamfi; Lori S Kim; Theodore S Jardetzky; Robert A Lamb
Journal:  J Virol       Date:  2016-09-29       Impact factor: 5.103

3.  Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins.

Authors:  Albert S Song; Taylor A Poor; Luciano A Abriata; Theodore S Jardetzky; Matteo Dal Peraro; Robert A Lamb
Journal:  Proc Natl Acad Sci U S A       Date:  2016-06-22       Impact factor: 11.205

4.  Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics.

Authors:  Ivy Widjaja; Alan Rigter; Shamir Jacobino; Frank J M van Kuppeveld; Kees Leenhouts; Concepción Palomo; Jose A Melero; Jeanette H W Leusen; Bert Jan Haijema; Peter J M Rottier; Cornelis A M de Haan
Journal:  PLoS One       Date:  2015-06-24       Impact factor: 3.240

5.  Novel Mammalian orthorubulavirus 5 Discovered as Accidental Cell Culture Contaminant.

Authors:  Brandi J Feehan; Aleksey A Penin; Alexey N Mukhin; Deepak Kumar; Anna S Moskvina; Kizkhalum M Khametova; Anton G Yuzhakov; Maria I Musienko; Alexey D Zaberezhny; Taras I Aliper; Douglas Marthaler; Konstantin P Alekseev
Journal:  Viruses       Date:  2019-08-23       Impact factor: 5.048
  5 in total

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