Literature DB >> 2558935

Insulin does not activate a phosphoinositide-specific phospholipase C in adipocytes.

R Etindi1, J N Fain.   

Abstract

Phosphoinositide-specific phospholipase C (PI-PLC) activity was determined in homogenates of adipocytes treated with maximal concentrations of insulin. PI-PLC activity measured using exogenous [3H]phosphatidylinositol [( 3H]PI) and exogenous [3H]phosphatidylinositol 4,5-bisphosphate [( 3H]PIP2) was not altered by prior exposure of adipocytes to insulin. It was possible to see oxytocin-induced breakdown of phosphoinositides but no effect of insulin was seen in intact adipocytes.

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Year:  1989        PMID： 2558935     DOI： 10.1016/0303-7207(89)90204-9

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  3 in total

1.  Insulin stimulates turnover of phosphatidylcholine in rat adipocytes.

Authors:  S L Macaulay; R G Larkins
Journal:  Mol Cell Biochem       Date:  1994-07-13       Impact factor: 3.396

2.  Isolation of insulin-sensitive phosphatidylinositol-glycan from rat adipocytes. Its impaired breakdown in the streptozotocin-diabetic rat.

Authors:  S L Macaulay; R G Larkins
Journal:  Biochem J       Date:  1990-10-15       Impact factor: 3.857

3.  Growth hormone inhibits activation of phosphatidylinositol phospholipase C in adipose plasma membranes: evidence for a growth hormone-induced change in G protein function.

Authors:  P Roupas; S Y Chou; R J Towns; J L Kostyo
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205
  3 in total

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