Literature DB >> 2558900

Isolated human bladder: evidence for an adenine dinucleotide acting on P2X-purinoceptors and for purinergic transmission.

C H Hoyle1, C Chapple, G Burnstock.   

Abstract

In isolated strips of human urinary bladder detrusor muscle, ATP, alpha, beta-methylene ATP and P1,P6-diadenosine hexaphosphate caused concentration-dependent contractions. ATP was less potent than the two synthetic purine compounds and gave smaller maximum responses. Responses to ATP, P1,P6-diadenosine hexaphosphate and noncholinergic nerve stimulation were blocked following desensitization of P2X-purinoceptors by alpha,beta-methylene ATP. Thus, adenine dinucleotides can act on P2X-purinoceptors and there is an element of purinergic neuromuscular transmission in the human urinary bladder.

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Year:  1989        PMID： 2558900     DOI： 10.1016/0014-2999(89)90881-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  24 in total

1.  Spontaneous phasic activity of the pig urinary bladder smooth muscle: characteristics and sensitivity to potassium channel modulators.

Authors:  Steven A Buckner; Ivan Milicic; Anthony V Daza; Michael J Coghlan; Murali Gopalakrishnan
Journal:  Br J Pharmacol       Date:  2002-02       Impact factor: 8.739

2.  P2X receptor expression in mouse urinary bladder and the requirement of P2X(1) receptors for functional P2X receptor responses in the mouse urinary bladder smooth muscle.

Authors:  C Vial; R J Evans
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

Review 3.  Pharmacology of P2X channels.

Authors:  Joel R Gever; Debra A Cockayne; Michael P Dillon; Geoffrey Burnstock; Anthony P D W Ford
Journal:  Pflugers Arch       Date:  2006-04-29       Impact factor: 3.657

Review 4.  Non-adrenergic, non-cholinergic control of the urinary bladder.

Authors:  C H Hoyle
Journal:  World J Urol       Date:  1994       Impact factor: 4.226

5.  Negative chronotropic and inotropic effects exerted by diadenosine hexaphosphate (AP6A) via A1-adenosine receptors.

Authors:  U Vahlensieck; P Bokník; J Knapp; B Linck; F U Müller; J Neumann; S Herzig; H Schlüter; W Zidek; M C Deng; H H Scheld; W Schmitz
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

6.  Effects of diadenosine polyphosphates, ATP and angiotensin II on cytosolic Ca2+ activity and contraction of rat mesangial cells.

Authors:  E Schlatter; I Ankorina; S Haxelmans; R Kleta
Journal:  Pflugers Arch       Date:  1995-09       Impact factor: 3.657

7.  Ap4A and ADP-beta-S binding to P2 purinoceptors present on rat brain synaptic terminals.

Authors:  J Pintor; M A Díaz-Rey; M T Miras-Portugal
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

8.  PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder.

Authors:  A U Ziganshin; C H Hoyle; X Bo; G Lambrecht; E Mutschler; H G Bäumert; G Burnstock
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

9.  Effects of PPADS and suramin on contractions and cytoplasmic Ca2+ changes evoked by AP4A, ATP and alpha, beta-methylene ATP in guinea-pig urinary bladder.

Authors:  S Usune; T Katsuragi; T Furukawa
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

10.  Spontaneous purinergic neurotransmission in the mouse urinary bladder.

Authors:  John S Young; En Meng; Tom C Cunnane; Keith L Brain
Journal:  J Physiol       Date:  2008-10-20       Impact factor: 5.182
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