| Literature DB >> 25588845 |
Abdur Rauf1, Ghias Uddin, Ajmal Khan, Bina S Siddiqui, Mohammad Arfan, Kourosh Dalvandi, Taibi Ben Hadda.
Abstract
A new triterpenic compound named pistagremic acid (PA) was once again isolated from Pistaciaintegerrima. The β-secretase inhibition study was carried out. Compound PA was found significantly active against β-secretase enzyme (BACE1) with IC50 value of 350 ± 2 nM in comparison to the standard inhibitors [Asn670, Sta671, Val672]-amyloid-β/A4 precursor protein 770 fragment 662-675 (IC50 = 290.71 ± 1 nM). The selectivity of this compound was also evaluated against the acetylcholinesterase and butyrylcholinesterase enzymes. Interestingly compound PA was found to be inactive against them and showed selectivity towards β-secretase enzyme (BACE1).Entities:
Keywords: Pistacia integerrima; acetylcholinesterase and butyrylcholinesterase; pistagremic acid; selectivity; triterpenoid; β-secretase
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Year: 2015 PMID： 25588845 DOI： 10.1080/14786419.2014.997231
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861