Hongyan Jiang1,2, Fei Qiao3, Zongfang Li4, Yaping Zhang1,5, Yuqi Cheng2, Xiufeng Xu2, Li Yu1. 1. Laboratory for Conservation and Utilization of Bio-resource, Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, Yunnan, China. 2. Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. 3. Department of Anesthesiology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. 4. Department of Radiology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. 5. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Abstract
INTRODUCTION: Genetic analyses including genome-wide association studies have reported an intronic single nucleotide polymorphism (SNP) rs1006737 in CACNA1C gene (encoded calcium channel, voltage-dependent, L type, alpha 1C subunit) as a risk factor for schizophrenia in European populations. The replications in other ethnic populations such as East Asians have also been conducted, but the results were inconsistent, either likely due to the limited sample size of single study or genetic heterogeneity between continental populations on this locus. METHODS: We performed a comprehensive meta-analysis of all available samples from existing studies of East Asian populations, including a total of 9,432 cases and 10,661 controls, to further confirm whether CACNA1C rs1006737 is an authentic risk SNP for schizophrenia in East Asian populations. RESULTS: Our results revealed a significant association between rs1006737 and schizophrenia (allelic model, P = 4.39 × 10(-6) , pooled odds ratio [OR] = 1.20), and the results were much strengthened when the European and East Asian samples were combined together (P = 2.40 × 10(-17) , pooled OR = 1.12). There is no significant heterogeneity or publication bias between individual studies, and removal of any single study still remained significant associations between rs1006737 and schizophrenia. DISCUSSION: Our results further confirmed that rs1006737 should be categorized as an authentic risk SNP for schizophrenia in the general populations.
INTRODUCTION: Genetic analyses including genome-wide association studies have reported an intronic single nucleotide polymorphism (SNP) rs1006737 in CACNA1C gene (encoded calcium channel, voltage-dependent, L type, alpha 1C subunit) as a risk factor for schizophrenia in European populations. The replications in other ethnic populations such as East Asians have also been conducted, but the results were inconsistent, either likely due to the limited sample size of single study or genetic heterogeneity between continental populations on this locus. METHODS: We performed a comprehensive meta-analysis of all available samples from existing studies of East Asian populations, including a total of 9,432 cases and 10,661 controls, to further confirm whether CACNA1Crs1006737 is an authentic risk SNP for schizophrenia in East Asian populations. RESULTS: Our results revealed a significant association between rs1006737 and schizophrenia (allelic model, P = 4.39 × 10(-6) , pooled odds ratio [OR] = 1.20), and the results were much strengthened when the European and East Asian samples were combined together (P = 2.40 × 10(-17) , pooled OR = 1.12). There is no significant heterogeneity or publication bias between individual studies, and removal of any single study still remained significant associations between rs1006737 and schizophrenia. DISCUSSION: Our results further confirmed that rs1006737 should be categorized as an authentic risk SNP for schizophrenia in the general populations.
Authors: Rick P F Wolthusen; Johanna Hass; Esther Walton; Jessica A Turner; Veit Rössner; Scott R Sponheim; Beng-Choon Ho; Daphne J Holt; Randy L Gollub; Vince Calhoun; Stefan Ehrlich Journal: World J Biol Psychiatry Date: 2015-08-07 Impact factor: 4.132