Literature DB >> 25588498

Soluble epoxide hydrolase inhibitory activity of phenolic components from the rhizomes and roots of Gentiana scabra.

Wei Li1, Jang Hoon Kim, Wei Zhou, Sang Hee Shim, Jin Yeul Ma, Young Ho Kim.   

Abstract

Two new (1 and 2) and seven known phenolic compounds were isolated from a methanol extract of the rhizomes and roots of Gentiana scabra. Their structures were identified by spectroscopic analysis and comparing with reported values. The inhibitory effects of each compound on soluble epoxide hydrolase (sEH) were evaluated. Among them, compounds 2, 6, and 9 potently inhibited sEH activity.

Entities:  

Keywords:  Gentiana scabra; Gentianaceae; phenolic compound; soluble epoxide hydrolase

Mesh：

Substances：

Year:  2015        PMID： 25588498     DOI： 10.1080/09168451.2014.1002451

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  4 in total

1.  Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use.

Authors:  Jun-Yan Liu; Christophe Morisseau; Huazhang Huang; Bruce D Hammock
Journal:  J Ethnopharmacol       Date:  2016-10-01       Impact factor: 4.360

Review 2.  A Review on Rhubarb-Derived Substances as Modulators of Cardiovascular Risk Factors-A Special Emphasis on Anti-Obesity Action.

Authors:  Oleksandra Liudvytska; Joanna Kolodziejczyk-Czepas
Journal:  Nutrients       Date:  2022-05-13       Impact factor: 6.706

Review 3.  Analytical Methods of Phytochemicals from the Genus Gentiana.

Authors:  Yan Xu; Ying Li; Katherine G Maffucci; Linfang Huang; Rui Zeng
Journal:  Molecules       Date:  2017-11-28       Impact factor: 4.411

Review 4.  Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products.

Authors:  Cheng-Peng Sun; Xin-Yue Zhang; Christophe Morisseau; Sung Hee Hwang; Zhan-Jun Zhang; Bruce D Hammock; Xiao-Chi Ma
Journal:  J Med Chem       Date:  2020-12-28       Impact factor: 7.446
  4 in total

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