BACKGROUND: Endothelial dysfunction is one of the most important early indicators of atherosclerosis in hypertension (HT) patients. Endocan has been reported to play a role in the pathophysiology of endothelial dysfunction. OBJECTIVE: We sought to assess whether serum endocan levels are correlated with the presence and severity of coronary artery disease (CAD) in patients with HT. METHODS: We measured endocan levels in 164 patients with HT and in 55 controls. The severity of CAD was assessed by the coronary atherosclerosis index scores. RESULTS: Serum endocan levels were independently correlated with the presence and severity of CAD in HT patients. CONCLUSION: Endocan might function as a useful biomarker for monitoring the development and progression of CAD in HT patients.
BACKGROUND:Endothelial dysfunction is one of the most important early indicators of atherosclerosis in hypertension (HT) patients. Endocan has been reported to play a role in the pathophysiology of endothelial dysfunction. OBJECTIVE: We sought to assess whether serum endocan levels are correlated with the presence and severity of coronary artery disease (CAD) in patients with HT. METHODS: We measured endocan levels in 164 patients with HT and in 55 controls. The severity of CAD was assessed by the coronary atherosclerosis index scores. RESULTS: Serum endocan levels were independently correlated with the presence and severity of CAD in HTpatients. CONCLUSION:Endocan might function as a useful biomarker for monitoring the development and progression of CAD in HTpatients.
Authors: Tolga Çimen; Murat Bilgin; Ahmet Akyel; Mehmet Ali Felekoğlu; Ali Nallbani; Şeyda Özdemir; Gönül Erden; Alpaslan Öztürk; Mehmet Doğan; Ekrem Yeter Journal: Korean Circ J Date: 2016-11-01 Impact factor: 3.243
Authors: Yu Ho Lee; Jin Sug Kim; Se-Yun Kim; Yang Gyun Kim; Ju-Young Moon; Kyung-Hwan Jeong; Tae Won Lee; Chun-Gyoo Ihm; Sang-Ho Lee Journal: Kidney Res Clin Pract Date: 2016-07-14