Literature DB >> 2558780

Melatonin inhibits cyclic AMP and cyclic GMP accumulation in the rat pituitary.

J Vanĕcek1, L Vollrath.   

Abstract

Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone. Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis. Inhibition of cyclic AMP accumulation is specific for melatonin, since its analogs N-acetylserotonin and 5-methoxytryptamine are 1000 times less potent. Cyclic nucleotides may thus serve as second messengers transducing the effect of melatonin on cellular level.

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Year:  1989        PMID： 2558780     DOI： 10.1016/0006-8993(89)90129-7

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  13 in total

1.  Aggregation of pigment granules in single cultured Xenopus laevis melanophores by melatonin analogues.

Authors:  D Sugden
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

Review 2.  [Work of the inner clock. Neuroanatomy of circadian systems of mammals].

Authors:  S Reuss
Journal:  Naturwissenschaften       Date:  1993-11

3.  Expression of melatonin receptors in arteries involved in thermoregulation.

Authors:  M Viswanathan; J T Laitinen; J M Saavedra
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

4.  Modulation by melatonin of glutamatergic synaptic transmission in the carp retina.

Authors:  Hai Huang; Shu-Chen Lee; Xiong-Li Yang
Journal:  J Physiol       Date:  2005-10-20       Impact factor: 5.182

5.  Melatonin potentiates rod signals to ON type bipolar cells in fish retina.

Authors:  Yong Ping; Hai Huang; Xin-Jun Zhang; Xiong-Li Yang
Journal:  J Physiol       Date:  2008-04-03       Impact factor: 5.182

6.  The Galphai and Galphaq proteins mediate the effects of melatonin on steroid/thyroid hormone receptor transcriptional activity and breast cancer cell proliferation.

Authors:  Ling Lai; Lin Yuan; Qi Chen; Chunmin Dong; Lulu Mao; Brian Rowan; Tripp Frasch; Steven M Hill
Journal:  J Pineal Res       Date:  2008-08-13       Impact factor: 13.007

Review 7.  Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

Authors:  R Jockers; P Maurice; J A Boutin; P Delagrange
Journal:  Br J Pharmacol       Date:  2008-05-19       Impact factor: 8.739

8.  Thermodynamic analysis of agonist and antagonist binding to the chicken brain melatonin receptor.

Authors:  N W Chong; D Sugden
Journal:  Br J Pharmacol       Date:  1994-01       Impact factor: 8.739

9.  Structural requirements at the melatonin receptor.

Authors:  D Sugden; N W Chong; D F Lewis
Journal:  Br J Pharmacol       Date:  1995-02       Impact factor: 8.739

Review 10.  Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders.

Authors:  Masaomi Miyamoto
Journal:  CNS Neurosci Ther       Date:  2009       Impact factor: 5.243
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