| Literature DB >> 25587754 |
Adrian L Smith1, Kristin L Andrews, Holger Beckmann, Steven F Bellon, Pedro J Beltran, Shon Booker, Hao Chen, Young-Ah Chung, Noel D D'Angelo, Jennifer Dao, Kenneth R Dellamaggiore, Peter Jaeckel, Richard Kendall, Katja Labitzke, Alexander M Long, Silvia Materna-Reichelt, Petia Mitchell, Mark H Norman, David Powers, Mark Rose, Paul L Shaffer, Michelle M Wu, J Russell Lipford.
Abstract
The structure-based design and optimization of a novel series of selective PERK inhibitors are described resulting in the identification of 44 as a potent, highly selective, and orally active tool compound suitable for PERK pathway biology exploration both in vitro and in vivo.Entities:
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Year: 2015 PMID： 25587754 DOI： 10.1021/jm5017494
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446