Guido Wassink1, Robert D Barrett1, Joanne O Davidson1, Laura Bennet1, Robert Galinsky1, Michael Dragunow1, Alistair J Gunn2. 1. From the Department of Physiology (G.W., R.D.B., J.O.D., L.B., R.G., A.J.G.), and Department of Anatomy with Radiology (M.D.), University of Auckland, Auckland, New Zealand. 2. From the Department of Physiology (G.W., R.D.B., J.O.D., L.B., R.G., A.J.G.), and Department of Anatomy with Radiology (M.D.), University of Auckland, Auckland, New Zealand. aj.gunn@auckland.ac.nz.
Abstract
BACKGROUND AND PURPOSE: Electroencephalographic recovery is predictive of outcome after perinatal hypoxia-ischemia, but it is unknown whether early changes in electroencephalographic can predict the response to therapeutic hypothermia in the preterm brain. METHODS: 0.7 gestation fetal sheep received umbilical cord occlusion or sham occlusion for 25 minutes, followed by sham hypothermia or whole-body cooling started either 30 minutes or 5 hours after occlusion and continued for 72 hours. RESULTS: Early but not delayed hypothermia reduced neuronal loss and microglial induction in the striatum, with faster recovery of spectral edge frequency, reduced seizure burden, and less suppression of electroencephalographic amplitude (P<0.05). CONCLUSIONS: Recovery of higher electroencephalographic frequencies may be a biomarker of effective hypothermic neuroprotection in the preterm-equivalent brain.
BACKGROUND AND PURPOSE: Electroencephalographic recovery is predictive of outcome after perinatal hypoxia-ischemia, but it is unknown whether early changes in electroencephalographic can predict the response to therapeutic hypothermia in the preterm brain. METHODS: 0.7 gestation fetal sheep received umbilical cord occlusion or sham occlusion for 25 minutes, followed by sham hypothermia or whole-body cooling started either 30 minutes or 5 hours after occlusion and continued for 72 hours. RESULTS: Early but not delayed hypothermia reduced neuronal loss and microglial induction in the striatum, with faster recovery of spectral edge frequency, reduced seizure burden, and less suppression of electroencephalographic amplitude (P<0.05). CONCLUSIONS: Recovery of higher electroencephalographic frequencies may be a biomarker of effective hypothermic neuroprotection in the preterm-equivalent brain.
Authors: Lotte G van den Heuij; Mhoyra Fraser; Suzanne L Miller; Graham Jenkin; Euan M Wallace; Joanne O Davidson; Christopher A Lear; Rebecca Lim; Guido Wassink; Alistair J Gunn; Laura Bennet Journal: J Cereb Blood Flow Metab Date: 2017-09-12 Impact factor: 6.200
Authors: Hamid Abbasi; Paul P Drury; Christopher A Lear; Alistair J Gunn; Joanne O Davidson; Laura Bennet; Charles P Unsworth Journal: Sci Rep Date: 2018-11-05 Impact factor: 4.379
Authors: Benjamin A Lear; Christopher A Lear; Joanne O Davidson; Jialin Sae-Jiw; Johanna M Lloyd; Alistair J Gunn; Laura Bennet Journal: Brain Commun Date: 2021-03-09
Authors: Joanne O Davidson; Lotte G van den Heuij; Mhoyra Fraser; Guido Wassink; Suzanne L Miller; Rebecca Lim; Euan M Wallace; Graham Jenkin; Alistair J Gunn; Laura Bennet Journal: Stem Cells Transl Med Date: 2020-10-26 Impact factor: 6.940