Literature DB >> 25586606

Nurse like cells: chronic lymphocytic leukemia associated macrophages.

Frédéric Boissard1, Jean-Jacques Fournié, Camille Laurent, Mary Poupot, Loïc Ysebaert.   

Abstract

CD14 + cells are able to differentiate into large and adherent cells if in contact with chronic lymphocytic leukemia (CLL) cells or healthy B lymphocytes. In CLL these cells, called CLL-nurse like cells (NLCs), express a very high amount of CD163 and CD68 and are able to rescue CLL cells through CCL4 production. Adherent cells derived from healthy donors, called HD-NLCs, express very little CD163 and CD68, do not produce CCL4 and are unable to rescue CCL cells. This study reveals that CLL-NLCs are the specific nurse cells in CLL, protecting CLL cells from death.

Entities:  

Keywords:  CD163; Chronic lymphocytic leukemia; nurse like cells; tumor-associated macrophages

Mesh：

Substances：

Year:  2015        PMID： 25586606     DOI： 10.3109/10428194.2014.991731

Source DB:  PubMed          Journal:  Leuk Lymphoma        ISSN： 1026-8022


  19 in total

1.  Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment.

Authors:  Sara Serra; Tiziana Vaisitti; Valentina Audrito; Cinzia Bologna; Roberta Buonincontri; Shih-Shih Chen; Francesca Arruga; Davide Brusa; Marta Coscia; Ozren Jaksic; Giorgio Inghirami; Davide Rossi; Richard R Furman; Simon C Robson; Gianluca Gaidano; Nicholas Chiorazzi; Silvia Deaglio
Journal:  Blood Adv       Date:  2016-11-22

2.  Disruption of Nurse-like Cell Differentiation as a Therapeutic Strategy for Chronic Lymphocytic Leukemia.

Authors:  Giovanna Merchand-Reyes; Ramasamy Santhanam; Frank H Robledo-Avila; Christoph Weigel; Juan de Dios Ruiz-Rosado; Xiaokui Mo; Santiago Partida-Sánchez; Jennifer A Woyach; Christopher C Oakes; Susheela Tridandapani; Jonathan P Butchar
Journal:  J Immunol       Date:  2022-08-22       Impact factor: 5.426

Review 3.  The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.

Authors:  Danny N Khalil; Eric L Smith; Renier J Brentjens; Jedd D Wolchok
Journal:  Nat Rev Clin Oncol       Date:  2016-03-15       Impact factor: 66.675

4.  Anti-CD20 monoclonal antibody-dependent phagocytosis of chronic lymphocytic leukaemia cells by autologous macrophages.

Authors:  A K Church; K R VanDerMeid; N A Baig; A M Baran; T E Witzig; G S Nowakowski; C S Zent
Journal:  Clin Exp Immunol       Date:  2015-10-28       Impact factor: 4.330

5.  Reprogramming Nurse-like Cells with Interferon γ to Interrupt Chronic Lymphocytic Leukemia Cell Survival.

Authors:  Shalini Gautam; Kavin Fatehchand; Saranya Elavazhagan; Brenda F Reader; Li Ren; Xiaokui Mo; John C Byrd; Susheela Tridandapani; Jonathan P Butchar
Journal:  J Biol Chem       Date:  2016-05-13       Impact factor: 5.157

Review 6.  The Bone Marrow Niche in B-Cell Acute Lymphoblastic Leukemia: The Role of Microenvironment from Pre-Leukemia to Overt Leukemia.

Authors:  Erica Dander; Chiara Palmi; Giovanna D'Amico; Giovanni Cazzaniga
Journal:  Int J Mol Sci       Date:  2021-04-23       Impact factor: 5.923

7.  Nurse-like cells impact on disease progression in chronic lymphocytic leukemia.

Authors:  F Boissard; C Laurent; A G Ramsay; A Quillet-Mary; J-J Fournié; M Poupot; L Ysebaert
Journal:  Blood Cancer J       Date:  2016-01-15       Impact factor: 11.037

8.  Nurse-like cells promote CLL survival through LFA-3/CD2 interactions.

Authors:  Loic Ysebaert; Mary Poupot; Frédéric Boissard; Marie Tosolini; Laetitia Ligat; Anne Quillet-Mary; Frederic Lopez; Jean-Jacques Fournié
Journal:  Oncotarget       Date:  2016-11-26

Review 9.  Targeting the Adenosinergic Axis in Chronic Lymphocytic Leukemia: A Way to Disrupt the Tumor Niche?

Authors:  Tiziana Vaisitti; Francesca Arruga; Silvia Deaglio
Journal:  Int J Mol Sci       Date:  2018-04-12       Impact factor: 5.923

Review 10.  The Role of Macrophage/B-Cell Interactions in the Pathophysiology of B-Cell Lymphomas.

Authors:  Lan V Pham; Elizabeth Pogue; Richard J Ford
Journal:  Front Oncol       Date:  2018-05-08       Impact factor: 6.244
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