| Literature DB >> 25586536 |
Piotr Iwanowski1, Jacek Losy2.
Abstract
Multiple sclerosis (MS), one of the most serious inflammatory and neurodegenerative conditions, is characterized by variable clinical courses - relapsing-remitting (RRMS), primary progressive (PPMS) and secondary progressive (SPMS). Although PPMS affects only 10-15% of the patient population, its course and pathophysiological and immunological background are distinct. In this review we present and discuss main differences between different types of MS, with particular focus on the underlying immunological mechanisms.Entities:
Keywords: Adhesion molecules; AntiGM3 antibodies; Demyelination; Neurodegeneration; PPMS; Primary progressive multiple sclerosis
Mesh:
Year: 2015 PMID: 25586536 DOI: 10.1016/j.jns.2014.12.035
Source DB: PubMed Journal: J Neurol Sci ISSN: 0022-510X Impact factor: 3.181