Literature DB >> 25586062

Effects of hnRNP A2/B1 Knockdown on Inhibition of Glioblastoma Cell Invasion, Growth and Survival.

Jinmu Deng1, Song Chen2, Feng Wang3, Hongxin Zhao4, Zongyi Xie3, Zhongye Xu3, Qingtao Zhang5, Ping Liang1, Xuan Zhai1, Yuan Cheng6.   

Abstract

Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) plays an important role in influence of pre-messenger RNA (pre-mRNA) processing and mRNA metabolism and transportation in cells. Increasing evidence indicates that hnRNP A2/B1 played an important role in development and progression of various human cancers. Forty cases of normal and human glioma tissue samples were analyzed using immunohistochemistry to reveal the expression of hnRNP A2/B1 protein in the samples. Then, knockdown of hnRNP A2/B1 expression induced by RNA interference (RNAi) method was used to analyze the role of hnRNP A2/B1 in glioblastoma cell viability, adhesion, migration, invasion, and chemoresistance for temozolomide (TMZ). The data showed that hnRNP A2/B1 protein was overexpressed in glioma tissue specimens and associated with advanced glioma grades. Knockdown of hnRNP A2/B1 could reduce glioblastoma cell viability, adhesion, migration, invasion, and chemoresistance for TMZ capacity, but induced tumor cells to apoptosis and reactive oxygen species (ROS) generation in glioma U251 and SHG44 cells. Molecularly, hnRNP A2/B1 knockdown reduced expression of phospho-STAT3 and MMP-2. Detection of hnRNP A2/B1 expression may be useful as a biomarker for prediction of glioma progression and knockdown of hnRNP A2/B1 expression as a novel strategy in future control of glioblastoma in clinic.

Entities:  

Keywords:  Cell growth; Cell invasion; Glioblastoma; hnRNP A2/B1; shRNA

Mesh：

Substances：

Year:  2015        PMID： 25586062     DOI： 10.1007/s12035-014-9080-3

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  44 in total

Review 1.  hnRNP complexes: composition, structure, and function.

Authors:  A M Krecic; M S Swanson
Journal:  Curr Opin Cell Biol       Date:  1999-06       Impact factor: 8.382

2.  CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells.

Authors:  Bo Mi Ku; Yeon Kyung Lee; Jinhyun Ryu; Joo Yeon Jeong; Jungil Choi; Keyoung Mi Eun; Hye Young Shin; Dong Gyu Kim; Eun Mi Hwang; Jae Cheal Yoo; Jae-Yong Park; Gu Seob Roh; Hyun Joon Kim; Gyeong Jae Cho; Wan Sung Choi; Sun Ha Paek; Sang Soo Kang
Journal:  Int J Cancer       Date:  2011-03-15       Impact factor: 7.396

3.  The role of caveolin-1 in blood-brain barrier disruption induced by focused ultrasound combined with microbubbles.

Authors:  Jinmu Deng; Qin Huang; Feng Wang; Yingjiang Liu; Zhibiao Wang; Zhigang Wang; Qingtao Zhang; Bo Lei; Yuan Cheng
Journal:  J Mol Neurosci       Date:  2011-08-23       Impact factor: 3.444

4.  Metformin inhibits leptin-induced growth and migration of glioblastoma cells.

Authors:  Rita Ferla; Eva Haspinger; Eva Surmacz
Journal:  Oncol Lett       Date:  2012-08-03       Impact factor: 2.967

5.  Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

Authors:  Michelle A Blaskovich; Jiazhi Sun; Alan Cantor; James Turkson; Richard Jove; Saïd M Sebti
Journal:  Cancer Res       Date:  2003-03-15       Impact factor: 12.701

Review 6.  Molecular mechanisms of glioma invasiveness: the role of proteases.

Authors:  Jasti S Rao
Journal:  Nat Rev Cancer       Date:  2003-07       Impact factor: 60.716

7.  Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators.

Authors:  Hui-Wen Lo; Xinyu Cao; Hu Zhu; Francis Ali-Osman
Journal:  Clin Cancer Res       Date:  2008-10-01       Impact factor: 12.531

8.  A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export.

Authors:  E Izaurralde; A Jarmolowski; C Beisel; I W Mattaj; G Dreyfuss; U Fischer
Journal:  J Cell Biol       Date:  1997-04-07       Impact factor: 10.539

9.  Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas.

Authors:  P A Forsyth; H Wong; T D Laing; N B Rewcastle; D G Morris; H Muzik; K J Leco; R N Johnston; P M Brasher; G Sutherland; D R Edwards
Journal:  Br J Cancer       Date:  1999-04       Impact factor: 7.640

10.  A nuclear localization domain in the hnRNP A1 protein.

Authors:  H Siomi; G Dreyfuss
Journal:  J Cell Biol       Date:  1995-05       Impact factor: 10.539
View more
  24 in total

1.  Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin.

Authors:  Kyoung-In Cho; Andrew Orry; Se Eun Park; Paulo A Ferreira
Journal:  ACS Chem Neurosci       Date:  2015-06-12       Impact factor: 4.418

2.  IE86 Inhibits the apoptosis and promotes the cell proliferation of glioma cells via the hnRNP A2/B1-mediated alternative splicing of Bcl-x.

Authors:  Rou Zhao; Ming Hu; Shuzhen Liang; Bin Wang; Bo Yu; Guimei Yang; Dongmeng Qian
Journal:  Int J Clin Exp Pathol       Date:  2019-07-01

Review 3.  Hypoxia-induced alternative splicing in human diseases: the pledge, the turn, and the prestige.

Authors:  Subhashis Natua; Cheemala Ashok; Sanjeev Shukla
Journal:  Cell Mol Life Sci       Date:  2021-01-02       Impact factor: 9.261

4.  A Risk Signature Consisting of Eight m6A Methylation Regulators Predicts the Prognosis of Glioma.

Authors:  Sizhong Guan; Ye He; Yanna Su; Liping Zhou
Journal:  Cell Mol Neurobiol       Date:  2021-08-25       Impact factor: 4.231

Review 5.  The Critical Role of RNA m6A Methylation in Gliomas: Targeting the Hallmarks of Cancer.

Authors:  Zhouhan Xu; Jun Jiang; Shun Wang
Journal:  Cell Mol Neurobiol       Date:  2022-09-15       Impact factor: 4.231

6.  HNRNPA2B1 regulates the epithelial-mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway.

Authors:  Shengjie Dai; Bicheng Chen; Mengtao Zhou; Jie Zhang; Shihao Huang; Bin Lou; Binbo Fang; Tingting Ye; Xince Huang
Journal:  Cancer Cell Int       Date:  2017-01-10       Impact factor: 5.722

7.  Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma.

Authors:  Bruna R Correa; Patricia Rosa de Araujo; Mei Qiao; Suzanne C Burns; Chen Chen; Richard Schlegel; Seema Agarwal; Pedro A F Galante; Luiz O F Penalva
Journal:  Genome Biol       Date:  2016-06-10       Impact factor: 13.583

8.  Effect of hnRNPA2/B1 on the proliferation and apoptosis of glioma U251 cells via the regulation of AKT and STAT3 pathways.

Authors:  Decheng Yin; Chengxiang Kong; Muhu Chen
Journal:  Biosci Rep       Date:  2020-07-31       Impact factor: 3.840

9.  Identification of castration-resistant prostate cancer-related hub genes using weighted gene co-expression network analysis.

Authors:  Yifei Cheng; Lu Li; Zongshi Qin; Xiao Li; Feng Qi
Journal:  J Cell Mol Med       Date:  2020-06-02       Impact factor: 5.310

10.  β-Asarone Induces Apoptosis and Cell Cycle Arrest of Human Glioma U251 Cells via Suppression of HnRNP A2/B1-Mediated Pathway In Vitro and In Vivo.

Authors:  Li Li; Yi Yang; Mingxia Wu; Zanyang Yu; Chengqiang Wang; Guojun Dou; Hui He; Hongmei Wang; Na Yang; Hongyi Qi; Xiaoyu Xu
Journal:  Molecules       Date:  2018-05-03       Impact factor: 4.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.