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Literature DB >> 25585804

Molecular crowding and early evolution.

Ranajay Saha¹, Andrew Pohorille, Irene A Chen.

Abstract

The environment of protocells might have been crowded with small molecules and functional and non-specific polymers. In addition to altering conformational equilibria, affecting reaction rates and changing the structure and activity of water, crowding might have enhanced the capabilities of protocells for evolutionary innovation through the creation of extended neutral networks in the fitness landscape.

Entities: Chemical

Mesh：

Substances：

Year: 2015 PMID： 25585804 DOI： 10.1007/s11084-014-9392-3

Source DB: PubMed Journal: Orig Life Evol Biosph ISSN： 0169-6149 Impact factor: 1.950

34 in total

1. The kinetic mechanism of the hairpin ribozyme in vivo: influence of RNA helix stability on intracellular cleavage kinetics.

Authors: C P Donahue; R S Yadava; S M Nesbitt; M J Fedor
Journal: J Mol Biol Date: 2000-01-21 Impact factor: 5.469

2. Increased ribozyme activity in crowded solutions.

Authors: Ravi Desai; Duncan Kilburn; Hui-Ting Lee; Sarah A Woodson
Journal: J Biol Chem Date: 2013-12-11 Impact factor: 5.157

Review 3. Evolutionary origins and directed evolution of RNA.

Authors: Andrew D Ellington; Xi Chen; Michael Robertson; Angel Syrett
Journal: Int J Biochem Cell Biol Date: 2008-08-19 Impact factor: 5.085

Review 4. Molecular crowding: analysis of effects of high concentrations of inert cosolutes on biochemical equilibria and rates in terms of volume exclusion.

Authors: A P Minton
Journal: Methods Enzymol Date: 1998 Impact factor: 1.600

5. Structural and dynamical characterization of unilamellar AOT vesicles in aqueous solutions and their efficacy as potential drug delivery vehicle.

Authors: Ranajay Saha; Pramod Kumar Verma; Rajib Kumar Mitra; Samir Kumar Pal
Journal: Colloids Surf B Biointerfaces Date: 2011-07-12 Impact factor: 5.268

6. Is water the universal solvent for life?

Authors: A Pohorille; L R Pratt
Journal: Orig Life Evol Biosph Date: 2012-10-12 Impact factor: 1.950

7. Protein stabilization by macromolecular crowding through enthalpy rather than entropy.

Authors: Michael Senske; Lisa Törk; Benjamin Born; Martina Havenith; Christian Herrmann; Simon Ebbinghaus
Journal: J Am Chem Soc Date: 2014-06-16 Impact factor: 15.419

8. Natural selection and the concept of a protein space.

Authors: J M Smith
Journal: Nature Date: 1970-02-07 Impact factor: 49.962

9. Tracer diffusion of globular proteins in concentrated protein solutions.

Authors: N Muramatsu; A P Minton
Journal: Proc Natl Acad Sci U S A Date: 1988-05 Impact factor: 11.205

10. The effect of macromolecular crowding on protein aggregation and amyloid fibril formation.

Authors: Larissa A Munishkina; Elisa M Cooper; Vladimir N Uversky; Anthony L Fink
Journal: J Mol Recognit Date: 2004 Sep-Oct Impact factor: 2.137

15 in total

1. Essentials in the life process indicated by the self-referential genetic code.

Authors: Romeu Cardoso Guimarães
Journal: Orig Life Evol Biosph Date: 2015-01-14 Impact factor: 1.950

2. Oligomerization of a Bimolecular Ribozyme Modestly Rescues its Structural Defects that Disturb Interdomain Assembly to Form the Catalytic Site.

Authors: Md Motiar Rahman; Shigeyoshi Matsumura; Yoshiya Ikawa
Journal: J Mol Evol Date: 2018-08-14 Impact factor: 2.395

3. The Origin(s) of Cell(s): Pre-Darwinian Evolution from FUCAs to LUCA : To Carl Woese (1928-2012), for his Conceptual Breakthrough of Cellular Evolution.

Authors: Shiping Tang
Journal: J Mol Evol Date: 2021-06-25 Impact factor: 2.395

Molecular crowding and early evolution.

1. The kinetic mechanism of the hairpin ribozyme in vivo: influence of RNA helix stability on intracellular cleavage kinetics.

2. Increased ribozyme activity in crowded solutions.

Review 3. Evolutionary origins and directed evolution of RNA.

Review 4. Molecular crowding: analysis of effects of high concentrations of inert cosolutes on biochemical equilibria and rates in terms of volume exclusion.

5. Structural and dynamical characterization of unilamellar AOT vesicles in aqueous solutions and their efficacy as potential drug delivery vehicle.

6. Is water the universal solvent for life?

7. Protein stabilization by macromolecular crowding through enthalpy rather than entropy.

8. Natural selection and the concept of a protein space.

9. Tracer diffusion of globular proteins in concentrated protein solutions.

10. The effect of macromolecular crowding on protein aggregation and amyloid fibril formation.

1. Essentials in the life process indicated by the self-referential genetic code.

2. Oligomerization of a Bimolecular Ribozyme Modestly Rescues its Structural Defects that Disturb Interdomain Assembly to Form the Catalytic Site.

3. The Origin(s) of Cell(s): Pre-Darwinian Evolution from FUCAs to LUCA : To Carl Woese (1928-2012), for his Conceptual Breakthrough of Cellular Evolution.

4. Prebiotic phosphorylation enabled by microdroplets.

5. Intrinsic concentration cycles and high ion fluxes in self-assembled precipitate membranes.

6. Vesicle encapsulation stabilizes intermolecular association and structure formation of functional RNA and DNA.

7. Dry/Wet Cycling and the Thermodynamics and Kinetics of Prebiotic Polymer Synthesis.

8. Chemical Transformations in Proto-Cytoplasmic Media. Phosphorus Coupling in the Silica Hydrogel Phase.

9. Lipid vesicles chaperone an encapsulated RNA aptamer.

10. A Hydrothermal-Sedimentary Context for the Origin of Life.