| Literature DB >> 25584888 |
David W Cescon1, Chiara Gorrini2, Tak W Mak3.
Abstract
In this issue of Cancer Cell, Schwartz and colleagues and Costa and colleagues demonstrate that inhibition of PI3Kα or PI3Kβ in cancer cells with hyperactivated PI3Kα or PI3Kβ, respectively, activates the other isoform, leading to a "rebound" of the PI3K activity through different compensation mechanisms.Entities:
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Year: 2015 PMID： 25584888 DOI： 10.1016/j.ccell.2014.12.003
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743