Literature DB >> 25584416

Comment on "structural determinants of drug partitioning in surrogates of phosphatidylcholine bilayer strata".

William E Acree1, Michela Brumfield1, Michael H Abraham2.   

Abstract

The Abraham model correlation for describing the partitioning behavior of solutes between water and hexadecane was redetermined using the measured partition coefficient data and solute descriptors derived from experimental data. The newly derived correlation provides a much better mathematical description of the observed partition coefficient data than the correlation given in the published paper.

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Keywords:  Abraham model; equilibrium; partition coefficients; phosphatidylcholine

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Year:  2015        PMID: 25584416     DOI: 10.1021/mp500382h

Source DB:  PubMed          Journal:  Mol Pharm        ISSN: 1543-8384            Impact factor:   4.939


  1 in total

1.  Response to "comment on 'structural determinants of drug partitioning in surrogates of phosphatidylcholine bilayer strata'".

Authors:  Stefan Balaz
Journal:  Mol Pharm       Date:  2015-03-27       Impact factor: 4.939

  1 in total

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