Literature DB >> 2558433

Reversal of drug resistance in Trypanosoma cruzi and Leishmania donovani by verapamil.

R A Neal1, J van Bueren, N G McCoy, M Iwobi.   

Abstract

Following previous studies of verapamil reversal of chloroquine resistance in malaria and multi-drug resistance in cancer cells, the effect of verapamil was investigated on nifurtimox-resistant Trypanosoma cruzi in vitro and antimony-resistant Leishmania donovani in vitro and in vivo. Verapamil alone was not active against either parasite, but in combination with nifurtimox it reversed the drug resistance of T. cruzi and in combination with sodium stibogluconate reversed the drug resistance of L. donovani.

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Year:  1989        PMID： 2558433     DOI： 10.1016/0035-9203(89)90642-1

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  16 in total

1.  Mechanism of amphotericin B resistance in clinical isolates of Leishmania donovani.

Authors:  Bidyut Purkait; Ashish Kumar; Nilay Nandi; Abul Hasan Sardar; Sushmita Das; Sudeep Kumar; Krishna Pandey; Vidyananda Ravidas; Manish Kumar; Tripti De; Dharmendra Singh; Pradeep Das
Journal:  Antimicrob Agents Chemother       Date:  2011-11-28       Impact factor: 5.191

2.  MAPK1 of Leishmania donovani modulates antimony susceptibility by downregulating P-glycoprotein efflux pumps.

Authors:  Mansi Garg; Neena Goyal
Journal:  Antimicrob Agents Chemother       Date:  2015-04-13       Impact factor: 5.191

3.  Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosis.

Authors:  Shashank Gupta; Keira A Cohen; Kathryn Winglee; Mamoudou Maiga; Bassirou Diarra; William R Bishai
Journal:  Antimicrob Agents Chemother       Date:  2013-10-14       Impact factor: 5.191

4.  Acceleration of tuberculosis treatment by adjunctive therapy with verapamil as an efflux inhibitor.

Authors:  Shashank Gupta; Sandeep Tyagi; Deepak V Almeida; Mariama C Maiga; Nicole C Ammerman; William R Bishai
Journal:  Am J Respir Crit Care Med       Date:  2013-09-01       Impact factor: 21.405

5.  The distribution of nifurtimox across the healthy and trypanosome-infected murine blood-brain and blood-cerebrospinal fluid barriers.

Authors:  Sinthujah Jeganathan; Lisa Sanderson; Murat Dogruel; Jean Rodgers; Simon Croft; Sarah A Thomas
Journal:  J Pharmacol Exp Ther       Date:  2010-11-05       Impact factor: 4.030

6.  Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection.

Authors:  Yara Almeida Machado; Maria Terezinha Bahia; Ivo Santana Caldas; Ana Lia Mazzeti; Rômulo Dias Novaes; Breno Raimundo Vilas Boas; Lorena Júnia de Souza Santos; Olindo Assis Martins-Filho; Marcos José Marques; Lívia de Figueiredo Diniz
Journal:  Antimicrob Agents Chemother       Date:  2020-07-22       Impact factor: 5.191

7.  Verapamil increases the bactericidal activity of bedaquiline against Mycobacterium tuberculosis in a mouse model.

Authors:  Shashank Gupta; Sandeep Tyagi; William R Bishai
Journal:  Antimicrob Agents Chemother       Date:  2014-10-20       Impact factor: 5.191

Review 8.  Practical guide for the treatment of leishmaniasis.

Authors:  R N Davidson
Journal:  Drugs       Date:  1998-12       Impact factor: 9.546

9.  Cross-resistance between cisplatin, antimony potassium tartrate, and arsenite in human tumor cells.

Authors:  P Naredi; D D Heath; R E Enns; S B Howell
Journal:  J Clin Invest       Date:  1995-03       Impact factor: 14.808

10.  P-glycoprotein efflux pump plays an important role in Trypanosoma cruzi drug resistance.

Authors:  Mônica Caroline Oliveira Campos; Denise Barçante Castro-Pinto; Grazielle Alves Ribeiro; Márcia Moreira Berredo-Pinho; Leonardo Henrique Ferreira Gomes; Myrtes Santos da Silva Bellieny; Carla Marins Goulart; Aurea Echevarria; Leonor Laura Leon
Journal:  Parasitol Res       Date:  2013-04-10       Impact factor: 2.289
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