Sonia Gupta1, Manjunath Sm2, Manveen Kaur Jawanda3, Achla Bharti4. 1. Senior Lecturer, Department of Oral Pathology, Swami Devi Dyal Hospital & Dental College , Golpura, Barwala, India . 2. Professor, Department of Oral Pathology, MMCDSR , Mullana, Ambala, India . 3. Professor & HOD, Department of Oral Pathology, Laxmibai institute of Dental Sciences and Hospital , Patiala, India . 4. Assistant Professor, Department of Oral Pathology, Govt Dental College , Rohtak, India .
Abstract
INTRODUCTION: Fibrinogen degradation products (FDPs) are the products that are released from fibrin/fibrinogen. Recently, it has been observed that these FDPs have been identified in the plasma of OSMF patients. Areca nut being the major aetiological agent for OSMF may play a role in the increased plasma levels of FDPs in OSMF. AIM: The aim of this study was to quantify the plasma FDPs levels in the individuals with the habit of areca nut chewing with and without OSMF. MATERIALS & METHODS: Total of 95 subjects were included,35 subjects with the habit of areca nut chewing with OSMF, 30 with the habit of areca nut chewing without OSMF, 30 without any habit of areca nut chewing without OSMF (control group). Five ml of venous blood was withdrawn from all the subjects and plasma FDP levels were estimated. RESULTS: Plasma FDPs were detected in all the subjects of OSMF but could not be detected in other two groups. As the clinical grades of OSMF increased, levels of plasma FDPs also increased. CONCLUSION: When plasma FDP increases, fibrin deposition also increases. This strengthens the finding that these FDPs may be an early indicator of the OSMF.
INTRODUCTION: Fibrinogen degradation products (FDPs) are the products that are released from fibrin/fibrinogen. Recently, it has been observed that these FDPs have been identified in the plasma of OSMF patients. Areca nut being the major aetiological agent for OSMF may play a role in the increased plasma levels of FDPs in OSMF. AIM: The aim of this study was to quantify the plasma FDPs levels in the individuals with the habit of areca nut chewing with and without OSMF. MATERIALS & METHODS: Total of 95 subjects were included,35 subjects with the habit of areca nut chewing with OSMF, 30 with the habit of areca nut chewing without OSMF, 30 without any habit of areca nut chewing without OSMF (control group). Five ml of venous blood was withdrawn from all the subjects and plasma FDP levels were estimated. RESULTS: Plasma FDPs were detected in all the subjects of OSMF but could not be detected in other two groups. As the clinical grades of OSMF increased, levels of plasma FDPs also increased. CONCLUSION: When plasma FDP increases, fibrin deposition also increases. This strengthens the finding that these FDPs may be an early indicator of the OSMF.
Authors: Megha Kadani; Satish B N V S; Maharudrappa B; Prashant K M; Deepa Hugar; Umesh Allad; Prasanth S Prabhu Journal: J Clin Diagn Res Date: 2014-05-15