| Literature DB >> 25584036 |
Kadir Demircan1, İsmail Cömertoğlu2, Sümeyya Akyol1, Beyza Nur Yiğitoğlu2, Esma Sarıkaya3.
Abstract
Playing a key role in the pathophysiology of many diseases, A Disintegrin-like and Metalloproteinase with Thrombospondin type-1 motif (ADAMTS) proteinases have been attracted more attention in obstetrics and gynecology. First discovered in 1997, this zinc-dependent proteinase family has 19 members today. These enzymes, which are located in the extracellular matrix (ECM), have a lot of very important functions, like matrix formation and resorption, angiogenesis, ovulation, and coagulation. In addition, in the pathogenesis of cancer, inflammation, arthritis, and connective tissue diseases, ADAMTS proteinases have crucial roles. The purpose of this review is to collect previous studies about obstetrics and gynecology that are related to ADAMTS enzymes and discuss the subject in many aspects to give an idea to the investigators who are interested in the subject.Entities:
Keywords: ADAMTS; biological marker; reproductive diseases
Year: 2014 PMID: 25584036 PMCID: PMC4285216 DOI: 10.5152/jtgga.2014.14206
Source DB: PubMed Journal: J Turk Ger Gynecol Assoc ISSN: 1309-0380