Neda Razaz1, Helen Tremlett2, W Thomas Boyce3, Martin Guhn1, K S Joseph4, Ruth Ann Marrie5. 1. School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, Canada. 2. Brain Research Centre and Department of Medicine (Division of Neurology), Faculty of Medicine, University of British Columbia, Vancouver, Canada/Vancouver Coastal Health Research Institute, Vancouver, Canada. 3. Departments of Pediatrics and Psychiatry, School of Medicine, University of California, San Francisco, USA. 4. School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, Canada/Department of Obstetrics & Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, Canada. 5. Departments of Internal Medicine and Community Health Sciences, College of Medicine, Faculty of Health Sciences, University of Manitoba Winnipeg, Canada rmarrie@hsc.mb.ca.
Abstract
BACKGROUND: Exposure to parental chronic illness is associated with several adverse developmental outcomes. OBJECTIVES: We examined the association between parental multiple sclerosis (MS) and childhood developmental outcomes. METHODS: We conducted a population-based retrospective cohort study in Manitoba, Canada, using linked databases. The outcome was childhood development at 5 years of age, expressed as vulnerability (absent vs. present) on the Early Development Instrument (EDI). Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Children with an MS parent (n=153) were similar to children of unaffected parents (n=876) on all EDI domains. However, mental health morbidity was more common among MS parents compared with non-MS parents 49.5% vs. 35.3%. Among MS parents, mental health morbidity was associated with children's vulnerability on the social competence (OR, 5.73 [95% CI:1.11-29.58]) and emotional maturity (OR, 3.03 [95% CI:1.03-8.94]) domains. The duration of child's exposure to parental MS was associated with vulnerability on the physical health domain (OR, 1.49 [95%CI:1.03-2.15]). CONCLUSION: Parental MS was not associated with adverse early childhood developmental outcomes. However, children of parents with mental health morbidity, and those with longer duration of exposure to parental MS, were at higher risk for early childhood developmental vulnerability.
BACKGROUND: Exposure to parental chronic illness is associated with several adverse developmental outcomes. OBJECTIVES: We examined the association between parental multiple sclerosis (MS) and childhood developmental outcomes. METHODS: We conducted a population-based retrospective cohort study in Manitoba, Canada, using linked databases. The outcome was childhood development at 5 years of age, expressed as vulnerability (absent vs. present) on the Early Development Instrument (EDI). Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). RESULTS:Children with an MS parent (n=153) were similar to children of unaffected parents (n=876) on all EDI domains. However, mental health morbidity was more common among MS parents compared with non-MS parents 49.5% vs. 35.3%. Among MS parents, mental health morbidity was associated with children's vulnerability on the social competence (OR, 5.73 [95% CI:1.11-29.58]) and emotional maturity (OR, 3.03 [95% CI:1.03-8.94]) domains. The duration of child's exposure to parental MS was associated with vulnerability on the physical health domain (OR, 1.49 [95%CI:1.03-2.15]). CONCLUSION: Parental MS was not associated with adverse early childhood developmental outcomes. However, children of parents with mental health morbidity, and those with longer duration of exposure to parental MS, were at higher risk for early childhood developmental vulnerability.
Authors: Neda Razaz; K S Joseph; W Thomas Boyce; Martin Guhn; Barry Forer; Robert Carruthers; Ruth Ann Marrie; Helen Tremlett Journal: Mult Scler Date: 2015-12-18 Impact factor: 6.312