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Literature DB >> 25583800

How does multistep tumorigenesis really proceed?

Christine L Chaffer¹, Robert A Weinberg².

Abstract

Identifying the cancer cells-of-origin is of great interest, as it holds the potential to elucidate biologic mechanisms inherent in the normal cell state that have been co-opted to drive the oncogenic cell state. An emerging concept, proposed here, states that cancer stem cells, key players in cancer initiation and metastasis, arise when transit-amplifying cells with mutant genomes dedifferentiate and enter the stem cell state. This model contrasts with the notion that cancer stem cells are the direct products of neoplastically transformed normal tissue stem cells. ©2015 American Association for Cancer Research.

Entities: Disease Gene Species

Mesh：

Year: 2015 PMID： 25583800 PMCID： PMC4295623 DOI： 10.1158/2159-8290.CD-14-0788

Source DB: PubMed Journal: Cancer Discov ISSN： 2159-8274 Impact factor: 39.397

10 in total

1. Cancer cells cyclically lose and regain drug-resistant highly tumorigenic features characteristic of a cancer stem-like phenotype.

Authors: Kaijie He; Tong Xu; Amir Goldkorn
Journal: Mol Cancer Ther Date: 2011-04-25 Impact factor: 6.261

2. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state.

Authors: Christine L Chaffer; Ines Brueckmann; Christina Scheel; Alicia J Kaestli; Paul A Wiggins; Leonardo O Rodrigues; Mary Brooks; Ferenc Reinhardt; Ying Su; Kornelia Polyak; Lisa M Arendt; Charlotte Kuperwasser; Brian Bierie; Robert A Weinberg
Journal: Proc Natl Acad Sci U S A Date: 2011-04-15 Impact factor: 11.205

3. Slug and Sox9 cooperatively determine the mammary stem cell state.

Authors: Wenjun Guo; Zuzana Keckesova; Joana Liu Donaher; Tsukasa Shibue; Verena Tischler; Ferenc Reinhardt; Shalev Itzkovitz; Aurelia Noske; Ursina Zürrer-Härdi; George Bell; Wai Leong Tam; Sendurai A Mani; Alexander van Oudenaarden; Robert A Weinberg
Journal: Cell Date: 2012-03-02 Impact factor: 41.582

4. Prospective identification of tumorigenic breast cancer cells.

Authors: Muhammad Al-Hajj; Max S Wicha; Adalberto Benito-Hernandez; Sean J Morrison; Michael F Clarke
Journal: Proc Natl Acad Sci U S A Date: 2003-03-10 Impact factor: 11.205

5. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.

Authors: D Bonnet; J E Dick
Journal: Nat Med Date: 1997-07 Impact factor: 53.440

6. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.

Authors: Sarah Schwitalla; Alexander A Fingerle; Patrizia Cammareri; Tim Nebelsiek; Serkan I Göktuna; Paul K Ziegler; Ozge Canli; Jarom Heijmans; David J Huels; Guenievre Moreaux; Rudolf A Rupec; Markus Gerhard; Roland Schmid; Nick Barker; Hans Clevers; Roland Lang; Jens Neumann; Thomas Kirchner; Makoto M Taketo; Gijs R van den Brink; Owen J Sansom; Melek C Arkan; Florian R Greten
Journal: Cell Date: 2012-12-27 Impact factor: 41.582

7. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells.

Authors: Piyush B Gupta; Christine M Fillmore; Guozhi Jiang; Sagi D Shapira; Kai Tao; Charlotte Kuperwasser; Eric S Lander
Journal: Cell Date: 2011-08-19 Impact factor: 41.582

8. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity.

Authors: Christine L Chaffer; Nemanja D Marjanovic; Tony Lee; George Bell; Celina G Kleer; Ferenc Reinhardt; Ana C D'Alessio; Richard A Young; Robert A Weinberg
Journal: Cell Date: 2013-07-03 Impact factor: 41.582

9. The clonal evolution of tumor cell populations.

Authors: P C Nowell
Journal: Science Date: 1976-10-01 Impact factor: 47.728

Review 10. Cells of origin in cancer.

Authors: Jane E Visvader
Journal: Nature Date: 2011-01-20 Impact factor: 49.962

10 in total

63 in total

Review 1. Mitostemness.

Authors: Elisabet Cuyàs; Sara Verdura; Núria Folguera-Blasco; Cristian Bastidas-Velez; Ángel G Martin; Tomás Alarcón; Javier A Menendez
Journal: Cell Cycle Date: 2018-07-02 Impact factor: 4.534

Review 2. Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract.

Authors: Jason C Mills; Owen J Sansom
Journal: Sci Signal Date: 2015-07-14 Impact factor: 8.192

How does multistep tumorigenesis really proceed?

1. Cancer cells cyclically lose and regain drug-resistant highly tumorigenic features characteristic of a cancer stem-like phenotype.

2. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state.

3. Slug and Sox9 cooperatively determine the mammary stem cell state.

4. Prospective identification of tumorigenic breast cancer cells.

5. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.

6. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.

7. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells.

8. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity.

9. The clonal evolution of tumor cell populations.

Review 10. Cells of origin in cancer.

Review 1. Mitostemness.

Review 2. Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract.

Review 3. Peptides encoded by noncoding genes: challenges and perspectives.

Review 4. Antigenic variability: Obstacles on the road to vaccines against traditionally difficult targets.

Review 5. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?

6. Expansion of cancer stem cell pool initiates lung cancer recurrence before angiogenesis.

Review 7. Emerging roles of p53 and other tumour-suppressor genes in immune regulation.

8. Role of TET1 and 5hmC in an Obesity-Linked Pathway Driving Cancer Stem Cells in Triple-Negative Breast Cancer.

Review 9. Shaping functional gut microbiota using dietary bioactives to reduce colon cancer risk.

10. A MASCOT for mosaic analysis.