| Literature DB >> 2558364 |
L A Cunningham1, M A Holzwarth.
Abstract
Using in vitro autoradiography, 125I-VIP binding was found to be concentrated in the capsule and glomerulosa of the rat adrenal cortex. The densest receptor distribution was coincident with the distribution of VIP nerve fibers that arborize extensively in the capsule and glomerulosa. The specificity of this binding was demonstrated using unlabelled VIP, ACTH and angiotensin II. The presence and distribution of 125I-VIP binding sites provides the link between the previously found VIP nerves and the steroidogenic effect of exogenous VIP, thereby substantiating the physiological role of VIP-containing autonomic nerves in the regulation of adrenocortical cell function.Entities:
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Year: 1989 PMID： 2558364 DOI： 10.1016/0196-9781(89)90196-4
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750