Literature DB >> 25583604

A direct method for the synthesis of orthogonally protected furyl- and thienyl- amino acids.

Alex S Hudson1, Laurent Caron, Neil Colgin, Steven L Cobb.   

Abstract

The synthesis of unnatural amino acids plays a key part in expanding the potential application of peptide-based drugs and in the total synthesis of peptide natural products. Herein, we report a direct method for the synthesis of orthogonally protected 5-membered heteroaromatic amino acids.

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Year:  2015        PMID: 25583604     DOI: 10.1007/s00726-014-1908-7

Source DB:  PubMed          Journal:  Amino Acids        ISSN: 0939-4451            Impact factor:   3.520


  2 in total

1.  Tetrafluoropyridyl (TFP): a general phenol protecting group readily cleaved under mild conditions.

Authors:  William D G Brittain; Steven L Cobb
Journal:  Org Biomol Chem       Date:  2019-02-20       Impact factor: 3.876

2.  Synthesis of pentafluorosulfanyl (SF5) containing aromatic amino acids.

Authors:  Lucas Grigolato; William D G Brittain; Alex S Hudson; Maria M Czyzewska; Steven L Cobb
Journal:  J Fluor Chem       Date:  2018-08       Impact factor: 2.050

  2 in total

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