Literature DB >> 25583493

Novel recurrently mutated genes in African American colon cancers.

Kishore Guda1, Martina L Veigl2, Vinay Varadan3, Arman Nosrati4, Lakshmeswari Ravi4, James Lutterbaugh4, Lydia Beard4, James K V Willson5, W David Sedwick6, Zhenghe John Wang7, Neil Molyneaux8, Alexander Miron8, Mark D Adams9, Robert C Elston10, Sanford D Markowitz11, Joseph E Willis12.   

Abstract

We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in African American CRCs. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. These previously unsuspected differences in the mutational landscapes of CRCs arising among individuals of different ethnicities have potential to impact on broader disparities in cancer behaviors.

Entities:  

Keywords:  African American; Caucasian; colon cancer; mutation; next-generation sequencing

Mesh：

Substances：

Year:  2015        PMID： 25583493      PMCID： PMC4313860          DOI： 10.1073/pnas.1417064112

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

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5.  Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome.

Authors:  Michael L Nickerson; Michelle B Warren; Jorge R Toro; Vera Matrosova; Gladys Glenn; Maria L Turner; Paul Duray; Maria Merino; Peter Choyke; Christian P Pavlovich; Nirmala Sharma; McClellan Walther; David Munroe; Rob Hill; Eamonn Maher; Cheryl Greenberg; Michael I Lerman; W Marston Linehan; Berton Zbar; Laura S Schmidt
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9.  The genomic landscapes of human breast and colorectal cancers.

Authors:  Laura D Wood; D Williams Parsons; Siân Jones; Jimmy Lin; Tobias Sjöblom; Rebecca J Leary; Dong Shen; Simina M Boca; Thomas Barber; Janine Ptak; Natalie Silliman; Steve Szabo; Zoltan Dezso; Vadim Ustyanksky; Tatiana Nikolskaya; Yuri Nikolsky; Rachel Karchin; Paul A Wilson; Joshua S Kaminker; Zemin Zhang; Randal Croshaw; Joseph Willis; Dawn Dawson; Michail Shipitsin; James K V Willson; Saraswati Sukumar; Kornelia Polyak; Ben Ho Park; Charit L Pethiyagoda; P V Krishna Pant; Dennis G Ballinger; Andrew B Sparks; James Hartigan; Douglas R Smith; Erick Suh; Nickolas Papadopoulos; Phillip Buckhaults; Sanford D Markowitz; Giovanni Parmigiani; Kenneth W Kinzler; Victor E Velculescu; Bert Vogelstein
Journal:  Science       Date:  2007-10-11       Impact factor: 47.728

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  59 in total

1.  miR-422a is an independent prognostic factor and functions as a potential tumor suppressor in colorectal cancer.

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Journal:  World J Gastroenterol       Date:  2016-06-28       Impact factor: 5.742

2.  Reply to Ashktorab et al.: Mutational landscape of colon cancers in African Americans.

Authors:  Kishore Guda; Martina L Veigl; Vinay Varadan; Arman Nosrati; Lakshmeswari Ravi; James Lutterbaugh; Lydia Beard; James K V Willson; W David Sedwick; Zhenghe John Wang; Neil Molyneaux; Alexander Miron; Mark D Adams; Robert C Elston; Sanford D Markowitz; Joseph E Willis
Journal:  Proc Natl Acad Sci U S A       Date:  2015-05-04       Impact factor: 11.205

3.  Next-generation sequencing in African Americans with colorectal cancer.

Authors:  Hassan Ashktorab; Sudhir Varma; Hassan Brim
Journal:  Proc Natl Acad Sci U S A       Date:  2015-05-04       Impact factor: 11.205

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Review 6.  Racial Disparity in Gastrointestinal Cancer Risk.

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7.  Lack of APC somatic mutation is associated with early-onset colorectal cancer in African Americans.

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8.  Adverse Clinical Outcome Associated With Mutations That Typify African American Colorectal Cancers.

Authors:  Zhenghe Wang; Li Li; Kishore Guda; Zhengyi Chen; Jill Barnholtz-Sloan; Young Soo Park; Sanford D Markowitz; Joseph Willis
Journal:  J Natl Cancer Inst       Date:  2016-08-31       Impact factor: 13.506

Review 9.  Colorectal Cancer Disparity in African Americans: Risk Factors and Carcinogenic Mechanisms.

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10.  Decreased copy-neutral loss of heterozygosity in African American colorectal cancers.

Authors:  Gaius J Augustus; Rosa M Xicola; Xavier Llor; Nathan A Ellis
Journal:  Genes Chromosomes Cancer       Date:  2020-04-29       Impact factor: 5.006
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