Literature DB >> 25583408

Total synthesis of trioxacarcin DC-45-A2.

K C Nicolaou1, Quan Cai, Bo Qin, Mette T Petersen, Remi J T Mikkelsen, Philipp Heretsch.   

Abstract

An enantioselective total synthesis of trioxacarcin DC-45-A2 (1) featuring a novel Lewis acid-induced cascade rearrangement of epoxyketone 6 to forge the polyoxygenated 2,7-dioxabicyclo[2.2.1]heptane core of the molecule is described.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  antitumor agents; cascade reactions; natural products; total synthesis; trioxacarcins

Mesh：

Substances：

Year:  2015        PMID： 25583408     DOI： 10.1002/anie.201410369

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  5 in total

1.  The SARP Family Regulator Txn9 and Two-Component Response Regulator Txn11 are Key Activators for Trioxacarcin Biosynthesis in Streptomyces bottropensis.

Authors:  Kui Yang; Li-Hua Qi; Mei Zhang; Xian-Feng Hou; Hai-Xue Pan; Gong-Li Tang; Wei Wang; Hua Yuan
Journal:  Curr Microbiol       Date:  2015-07-16       Impact factor: 2.188

2.  Total Synthesis of (±)-Phyllantidine: Development and Mechanistic Evaluation of a Ring Expansion for Installation of Embedded Nitrogen-Oxygen Bonds.

Authors:  Kyle M Lambert; Joshua B Cox; Lin Liu; Amy C Jackson; Sam Yruegas; Kenneth B Wiberg; John L Wood
Journal:  Angew Chem Int Ed Engl       Date:  2020-05-08       Impact factor: 15.336

3.  Ti(Oi-Pr)4-promoted photoenolization Diels-Alder reaction to construct polycyclic rings and its synthetic applications.

Authors:  Baochao Yang; Kuaikuai Lin; Yingbo Shi; Shuanhu Gao
Journal:  Nat Commun       Date:  2017-09-20       Impact factor: 14.919

Review 4.  Advances in the Asymmetric Total Synthesis of Natural Products Using Chiral Secondary Amine Catalyzed Reactions of α,β-Unsaturated Aldehydes.

Authors:  Zhonglei Wang
Journal:  Molecules       Date:  2019-09-19       Impact factor: 4.411

5.  Metabolomics Tools Assisting Classic Screening Methods in Discovering New Antibiotics from Mangrove Actinomycetia in Leizhou Peninsula.

Authors:  Qin-Pei Lu; Yong-Mei Huang; Shao-Wei Liu; Gang Wu; Qin Yang; Li-Fang Liu; Hai-Tao Zhang; Yi Qi; Ting Wang; Zhong-Ke Jiang; Jun-Jie Li; Hao Cai; Xiu-Jun Liu; Hui Luo; Cheng-Hang Sun
Journal:  Mar Drugs       Date:  2021-12-01       Impact factor: 5.118
  5 in total

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