Literature DB >> 25583167

Human Influenza A Virus-Specific CD8+ T-Cell Response Is Long-lived.

Carolien E van de Sandt1, Marine L B Hillaire1, Martina M Geelhoed-Mieras1, Albert D M E Osterhaus2, Ron A M Fouchier1, Guus F Rimmelzwaan2.   

Abstract

Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  CD8+ T cells; human; immunity; influenza A virus; longevity

Mesh:

Year:  2015        PMID: 25583167      PMCID: PMC4542594          DOI: 10.1093/infdis/jiv018

Source DB:  PubMed          Journal:  J Infect Dis        ISSN: 0022-1899            Impact factor:   5.226


  15 in total

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Authors:  Carolien E van de Sandt; Joost H C M Kreijtz; Gerrie de Mutsert; Martina M Geelhoed-Mieras; Marine L B Hillaire; Stella E Vogelzang-van Trierum; Albert D M E Osterhaus; Ron A M Fouchier; Guus F Rimmelzwaan
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