| Literature DB >> 25583167 |
Carolien E van de Sandt1, Marine L B Hillaire1, Martina M Geelhoed-Mieras1, Albert D M E Osterhaus2, Ron A M Fouchier1, Guus F Rimmelzwaan2.
Abstract
Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.Entities:
Keywords: CD8+ T cells; human; immunity; influenza A virus; longevity
Mesh:
Year: 2015 PMID: 25583167 PMCID: PMC4542594 DOI: 10.1093/infdis/jiv018
Source DB: PubMed Journal: J Infect Dis ISSN: 0022-1899 Impact factor: 5.226