| Literature DB >> 25582635 |
Nikos V Margaritelis1, Aristidis S Veskoukis, Vassilis Paschalis, Ioannis S Vrabas, Konstantina Dipla, Andreas Zafeiridis, Antonios Kyparos, Michalis G Nikolaidis.
Abstract
We examined whether the levels of oxidative stress biomarkers measured in blood reflect the tissue redox status. Data from studies that measured redox biomarkers in blood, heart, liver, kidney and skeletal muscle were analyzed. In seven out of nine investigated redox biomarkers (malondialdehyde, reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase, vitamin C and E) there was generally good qualitative and quantitative agreement between the blood and tissues. In contrast, oxidized glutathione and the reduced to oxidized glutathione ratio showed poor agreement between the blood and tissues. This study suggests that most redox biomarkers measured in blood adequately reflect tissue redox status.Entities:
Keywords: Antioxidant; biomarkers; blood; muscle; oxidative stress; tissues
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Year: 2015 PMID： 25582635 DOI： 10.3109/1354750X.2014.1002807
Source DB: PubMed Journal: Biomarkers ISSN： 1354-750X Impact factor: 2.658