Literature DB >> 25582341

Regulation of CD4 T-cell differentiation and inflammation by repressive histone methylation.

Frann Antignano1, Colby Zaph1.   

Abstract

Repressive epigenetic modifications such as dimethylation and trimethylation histone H3 at lysine 9 (H3K9me2 and H3K9me3) and H3K27me3 have been shown to be critical for embryonic stem (ES) cell differentiation by silencing cell lineage-promiscuous genes. CD4(+) T helper (T(H)) cell differentiation is a powerful model to study the molecular mechanisms associated with cellular lineage choice in adult cells. Naïve T(H) cells have the capacity to differentiate into one of the several phenotypically and functionally distinct and stable lineages. Although some repressive epigenetic mechanisms have a critical role in T(H) cell differentiation in a similar manner to that in ES cells, it is clear that there are disparate functions for certain modifications between ES cells and T(H) cells. Here we review the role of repressive histone modifications in the differentiation and function of T(H) cells in health and disease.

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Year:  2015        PMID： 25582341     DOI： 10.1038/icb.2014.115

Source DB:  PubMed          Journal:  Immunol Cell Biol        ISSN： 0818-9641            Impact factor:   5.126


  120 in total

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10.  A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

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Journal:  Nature       Date:  2012-08-16       Impact factor: 49.962
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