Giovanni Succo1, Erika Crosetti2, Andy Bertolin3, Marco Lucioni3, Alessandra Caracciolo1, Valentina Panetta4, Andrea Elio Sprio5, Giovanni Nicolao Berta5, Giuseppe Rizzotto3. 1. Otorhinolaryngology Service, Department of Oncology, San Luigi Gonzaga Hospital, University of Turin, Turin, Italy. 2. Otorhinolaryngology Service, Martini Hospital, Turin, Italy. 3. Otorhinolaryngology Service, Vittorio Veneto Hospital, Vittorio Veneto, Treviso, Italy. 4. L'altrastatistica srl, Consultancy and Training, Biostatistics Office, Rome, Italy. 5. Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Abstract
BACKGROUND: Laryngeal squamous cell carcinoma (SCC) accounts for 1.9% of cancers worldwide. Most of these are diagnosed in the early stages (T1-T2, and N0). For these, a larynx preserving/conserving option is preferable. Beyond transoral laser microsurgery (TLM), open partial horizontal laryngectomy is a function-sparing surgical technique used to treat laryngeal SCC. METHODS: We retrospectively analyzed the clinical outcomes of 216 patients who underwent open partial horizontal laryngectomy for glottic cT2 laryngeal cancer. RESULTS: Five-year overall survival (OS), disease-specific survival (DFS), locoregional control, local control, laryngeal function preservation, and laryngectomy-free survival rates were 93.1%, 98.0%, 97.1%, 97.5%, 97.8%, and 98.5%, respectively. Disease controls were significantly affected by previous treatment and type of surgery used. CONCLUSION: Although TLM for cT2 laryngeal cancer with unimpaired vocal cord mobility still represents a sound option, open partial horizontal laryngectomy offers higher local control and laryngeal preservation rates for selected patients with impaired mobility of vocal cords combined with involvement of the paraglottic space.
BACKGROUND: Laryngeal squamous cell carcinoma (SCC) accounts for 1.9% of cancers worldwide. Most of these are diagnosed in the early stages (T1-T2, and N0). For these, a larynx preserving/conserving option is preferable. Beyond transoral laser microsurgery (TLM), open partial horizontal laryngectomy is a function-sparing surgical technique used to treat laryngeal SCC. METHODS: We retrospectively analyzed the clinical outcomes of 216 patients who underwent open partial horizontal laryngectomy for glottic cT2laryngeal cancer. RESULTS: Five-year overall survival (OS), disease-specific survival (DFS), locoregional control, local control, laryngeal function preservation, and laryngectomy-free survival rates were 93.1%, 98.0%, 97.1%, 97.5%, 97.8%, and 98.5%, respectively. Disease controls were significantly affected by previous treatment and type of surgery used. CONCLUSION: Although TLM for cT2laryngeal cancer with unimpaired vocal cord mobility still represents a sound option, open partial horizontal laryngectomy offers higher local control and laryngeal preservation rates for selected patients with impaired mobility of vocal cords combined with involvement of the paraglottic space.
Authors: Andressa Silva de Freitas; Izabella C Santos; Cristina Furia; Rodrigo Dornelas; Ana Catarina Alves E Silva; Fernando Luiz Dias; Gil F Salles Journal: Eur Arch Otorhinolaryngol Date: 2022-01-04 Impact factor: 2.503
Authors: F Ricciardiello; R Capasso; H Kawasaki; T Abate; F Oliva; A Lombardi; G Misso; D Ingrosso; C A Leone; M Iengo; M Caraglia Journal: Acta Otorhinolaryngol Ital Date: 2017-12 Impact factor: 2.124
Authors: E Crosetti; A Caracciolo; G Molteni; A E Sprio; G N Berta; L Presutti; G Succo Journal: Acta Otorhinolaryngol Ital Date: 2016-06 Impact factor: 2.124
Authors: Cesare Piazza; Marta Filauro; Alberto Paderno; Filippo Marchi; Pietro Perotti; Riccardo Morello; Stefano Taboni; Giampiero Parrinello; Fabiola Incandela; Andrea Iandelli; Francesco Missale; Giorgio Peretti Journal: Front Oncol Date: 2018-05-22 Impact factor: 6.244