| Literature DB >> 2558133 |
H G Bernstein1, S Bruszis, D Schmidt, B Wiederanders, A Dorn.
Abstract
The aspartic endopeptidase cathepsin D was immunolocalized in 21 human cadaver brains from patients with dementia and controls. Immunoreactive cathepsin D was found to be present in multiple neurons, neuritic plaques, some macroglial cells, and microvessels. It is suggested that the enzyme might be involved in certain posttranslational changes of cystoskeletal compounds that lead to the formation and/or further growth of neuritic plaques and neurofibrillary tangles.Entities:
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Year: 1989 PMID： 2558133
Source DB: PubMed Journal: J Hirnforsch ISSN： 0021-8359