Isabela M Benseñor1,2, Maria Angélica Nunes3, Maria de Fátima Sander Diniz4, Itamar S Santos1,2, André R Brunoni1,5, Paulo A Lotufo1,2. 1. Centro de Pesquisa Clínica, Hospital Universitário, Universidade de Sao Paulo, Sao Paulo, Brazil. 2. Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil. 3. Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. 4. Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 5. Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
Abstract
OBJECTIVE: To evaluate the association between subclinical thyroid dysfunction and psychiatric disorders using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). DESIGN: Cross-sectional study. PATIENTS: The study included 12 437 participants from the ELSA-Brasil with normal thyroid function (92·8%), 193 (1·4%) with subclinical hyperthyroidism and 784 (5·8%) with subclinical hypothyroidism, totalling 13 414 participants (50·6% of women). MEASUREMENTS: The mental health diagnoses of participants were assessed by trained raters using the Clinical Interview Schedule - Revised (CIS-R) and grouped according to the International Classification of Diseases 10 (ICD-10). Thyroid dysfunction was assessed using TSH and FT4 as well as routine use of thyroid hormones or antithyroid medications. Logistic models were presented using psychiatric disorders as the dependent variable and subclinical thyroid disorders as the independent variable. All logistic models were corrected for multiple comparisons using Bonferroni correction. RESULTS: After multivariate adjustment for possible confounders, we found a direct association between subclinical hyperthyroidism and panic disorder odds ratio [OR], 2·55; 95% confidence Interval (95% CI), 1·09-5·94; and an inverse association between subclinical hypothyroidism and generalized anxiety disorder (OR, 0·75; 95% CI, 0·59-0·96). However, both lost significance after correction for multiple comparisons. CONCLUSION: Subclinical hyperthyroidism was positively associated with panic disorder and negatively associated with anxiety disorder, although not significant after adjustment for multiple comparisons.
OBJECTIVE: To evaluate the association between subclinical thyroid dysfunction and psychiatric disorders using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). DESIGN: Cross-sectional study. PATIENTS: The study included 12 437 participants from the ELSA-Brasil with normal thyroid function (92·8%), 193 (1·4%) with subclinical hyperthyroidism and 784 (5·8%) with subclinical hypothyroidism, totalling 13 414 participants (50·6% of women). MEASUREMENTS: The mental health diagnoses of participants were assessed by trained raters using the Clinical Interview Schedule - Revised (CIS-R) and grouped according to the International Classification of Diseases 10 (ICD-10). Thyroid dysfunction was assessed using TSH and FT4 as well as routine use of thyroid hormones or antithyroid medications. Logistic models were presented using psychiatric disorders as the dependent variable and subclinical thyroid disorders as the independent variable. All logistic models were corrected for multiple comparisons using Bonferroni correction. RESULTS: After multivariate adjustment for possible confounders, we found a direct association between subclinical hyperthyroidism and panic disorder odds ratio [OR], 2·55; 95% confidence Interval (95% CI), 1·09-5·94; and an inverse association between subclinical hypothyroidism and generalized anxiety disorder (OR, 0·75; 95% CI, 0·59-0·96). However, both lost significance after correction for multiple comparisons. CONCLUSION: Subclinical hyperthyroidism was positively associated with panic disorder and negatively associated with anxiety disorder, although not significant after adjustment for multiple comparisons.
Authors: Élida Campos; Carmen Freire; Fernando Barbosa; Cristina Lemos; Valéria Saraceni; Rosalina J Koifman; Rafael do Nascimento Pinheiro; Ilce Ferreira da Silva Journal: Int J Environ Res Public Health Date: 2021-11-26 Impact factor: 3.390
Authors: Benjamín Romero-Gómez; Paula Guerrero-Alonso; Juan Manuel Carmona-Torres; Blanca Notario-Pacheco; Ana Isabel Cobo-Cuenca Journal: Int J Environ Res Public Health Date: 2019-11-28 Impact factor: 3.390