PURPOSES: To evaluate the effects of axial length and age on the circumpapillary retinal nerve fiber layer (cpRNFL) and the inner macular parameters measured using 3 spectral-domain optical coherence tomography (OCT) instruments. METHODS: A total of 102 normal eyes (1 eye per subject) were imaged using Cirrus, RTVue, and 3D-OCT. The cpRNFL and the macular retinal nerve fiber layer (mRNFL), the ganglion cell layer+inner plexiform layer (GCLIPL), and the mRNFL+GCLIPL ganglion cell complex, GCC thicknesses were analyzed. The correlations between these values and the axial length or age were evaluated using a partial correlation analysis. These correlations were corrected using the axial length-related magnification effect. RESULTS: All but the nasal quadrant cpRNFL thicknesses and GCC thicknesses obtained using the 3 OCT instruments were significantly correlated with age. The average cpRNFL thickness and GCC thickness measured using the Cirrus and RTVue, but not by the 3D-OCT, had a negative correlation with the axial length. The temporal quadrant cpRNFL thickness measured using the 3 instruments was positively correlated with the axial length. The magnification correction made the most correlations positive. CONCLUSIONS: The average cpRNFL and GCC thicknesses measured using these 3 instruments decreased with age. The axial length affected the cpRNFL and GCC thicknesses as measured using the Cirrus and RTVue; this effect likely depended on the fundus area of analyses.
PURPOSES: To evaluate the effects of axial length and age on the circumpapillary retinal nerve fiber layer (cpRNFL) and the inner macular parameters measured using 3 spectral-domain optical coherence tomography (OCT) instruments. METHODS: A total of 102 normal eyes (1 eye per subject) were imaged using Cirrus, RTVue, and 3D-OCT. The cpRNFL and the macular retinal nerve fiber layer (mRNFL), the ganglion cell layer+inner plexiform layer (GCLIPL), and the mRNFL+GCLIPL ganglion cell complex, GCC thicknesses were analyzed. The correlations between these values and the axial length or age were evaluated using a partial correlation analysis. These correlations were corrected using the axial length-related magnification effect. RESULTS: All but the nasal quadrant cpRNFL thicknesses and GCC thicknesses obtained using the 3 OCT instruments were significantly correlated with age. The average cpRNFL thickness and GCC thickness measured using the Cirrus and RTVue, but not by the 3D-OCT, had a negative correlation with the axial length. The temporal quadrant cpRNFL thickness measured using the 3 instruments was positively correlated with the axial length. The magnification correction made the most correlations positive. CONCLUSIONS: The average cpRNFL and GCC thicknesses measured using these 3 instruments decreased with age. The axial length affected the cpRNFL and GCC thicknesses as measured using the Cirrus and RTVue; this effect likely depended on the fundus area of analyses.
Authors: P Carpineto; L Toto; R Aloia; V Ciciarelli; E Borrelli; E Vitacolonna; M Di Nicola; L Di Antonio; R Mastropasqua Journal: Eye (Lond) Date: 2016-02-12 Impact factor: 3.775
Authors: Chunwei Zhang; Andrew J Tatham; Ricardo Y Abe; Na'ama Hammel; Akram Belghith; Robert N Weinreb; Felipe A Medeiros; Jeffrey M Liebmann; Christopher A Girkin; Linda M Zangwill Journal: PLoS One Date: 2016-08-18 Impact factor: 3.240
Authors: Xinbo Zhang; Brian A Francis; Anna Dastiridou; Vikas Chopra; Ou Tan; Rohit Varma; David S Greenfield; Joel S Schuman; David Huang Journal: Transl Vis Sci Technol Date: 2016-03-04 Impact factor: 3.283