| Literature DB >> 2557967 |
A Adem1, S S Jossan, R d'Argy, P G Gillberg, A Nordberg, B Winblad, V Sara.
Abstract
The distribution of Insulin-like growth factor 1 (IGF-1) receptors in large cryosections of human brain hemispheres (80-microns) was studied by quantitative autoradiography using 125I-IGF-1 as ligand. Postmortem tissue only from individuals free from neurological diseases was used. The highest densities of IGF-1 receptors were found in the hippocampus, amygdala and parahippocampal gyrus. Intermediate densities were observed in the cerebellum, cerebral cortex and caudate nucleus, whereas low densities of IGF-1 receptors were obtained in the substantia nigra, red nucleus, white matter and cerebral pedunculus. The cartography of IGF-1 receptors in the normal human brain will hopefully be of use in the study of the alteration of these receptors in diseased brain.Entities:
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Year: 1989 PMID： 2557967 DOI： 10.1016/0006-8993(89)91678-8
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252