Literature DB >> 25579652

Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry.

F Cagide1, T Silva, J Reis, A Gaspar, F Borges, L R Gomes, J N Low.   

Abstract

The discovery of potent and selective monoamine oxidase-B inhibitors for the management of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is still a challenging endeavor. Herein, we report the discovery of two new classes of potent and selective MAO-B inhibitors based on chromane-2,4-dione and chromone-3-carboxamide scaffolds.

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Year:  2015        PMID： 25579652     DOI： 10.1039/c4cc08798d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Synthesis and evaluation of chromone derivatives as inhibitors of monoamine oxidase.

Authors:  Annah N Mpitimpiti; Jacobus P Petzer; Anél Petzer; Johannes H L Jordaan; Anna C U Lourens
Journal:  Mol Divers       Date:  2019-01-21       Impact factor: 2.943

2.  New insights in the discovery of novel h-MAO-B inhibitors: structural characterization of a series of N-phenyl-4-oxo-4H-chromene-3-carboxamide derivatives.

Authors:  Ligia R Gomes; John Nicolson Low; Fernando Cagide; Daniel Chavarria; Fernanda Borges
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-04-25

3.  Crystal structures of ethyl 6-(4-methyl-phen-yl)-4-oxo-4H-chromene-2-carboxyl-ate and ethyl 6-(4-fluoro-phen-yl)-4-oxo-4H-chromene-2-carboxyl-ate.

Authors:  Ligia R Gomes; John Nicolson Low; Carlos Fernandes; Alexandra Gaspar; Fernanda Borges
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-01-01

4.  Crystal structures and Hirshfeld surface analyses of (E)-N'-benzyl-idene-2-oxo-2H-chromene-3-carbo-hydrazide and the disordered hemi-DMSO solvate of (E)-2-oxo-N'-(3,4,5-trimeth-oxybenzyl-idene)-2H-chromene-3-carbohydrazide: lattice energy and inter-molecular inter-action energy calculations for the former.

Authors:  Ligia R Gomes; John Nicolson Low; James L Wardell; Camiola Capelini; Vitoria R F Câmara; Edson F da Silva; Samir A Carvalho
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-09-03

5.  A comparison of the structures of some 2- and 3-substituted chromone derivatives: a structural study on the importance of the secondary carboxamide backbone for the inhibitory activity of MAO-B.

Authors:  Ligia R Gomes; John Nicolson Low; Fernando Cagide; Alexandra Gaspar; Fernanda Borges
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-10-03
  5 in total

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