| Literature DB >> 25578863 |
A M Dygai1, V V Zhdanov, L A Miroshnichenko, E V Udut, G N Zyuz'kov, E V Simanina, A V Chaikovskii, L A Stavrova, E S Trofimova, Ya V Burmina.
Abstract
We studied the role of signaling pathways in the regulation of erythropoiesis against the background of myelosuppression caused by administration of 5-fluorouracil. The important role of cyclic AMP in the maturation of erythroid progenitors after cytostatic treatment was demonstrated. The secretory activity of myelokaryocytes during the period of erythroid hemopoiesis recovery is mainly regulated via the p38 MAPK signaling pathway; non-erythropoietin factors are involved in the formation of erythropoietic activity of adherent cells of the microenvironment.Entities:
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Year: 2015 PMID： 25578863 DOI： 10.1007/s10517-015-2747-6
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804