PURPOSE: This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folate-related enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population. METHODS: The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males. RESULTS: We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility. CONCLUSIONS: There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.
PURPOSE: This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folate-related enzyme genes: MTHFRC677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population. METHODS: The polymorphic distributions of the four SNPs (MTHFRC677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males. RESULTS: We found no evidence for an association between any of these variants (MTHFRC677T and A1298C, MTR A2756G and MTRR A66G) and male infertility. CONCLUSIONS: There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.
Authors: Doaa S Mfady; May F Sadiq; Omar F Khabour; Abdulfattah S Fararjeh; Aymen Abu-Awad; Yousef Khader Journal: Gene Date: 2013-12-12 Impact factor: 3.688
Authors: N M van der Put; F Gabreëls; E M Stevens; J A Smeitink; F J Trijbels; T K Eskes; L P van den Heuvel; H J Blom Journal: Am J Hum Genet Date: 1998-05 Impact factor: 11.025
Authors: Z Chen; A C Karaplis; S L Ackerman; I P Pogribny; S Melnyk; S Lussier-Cacan; M F Chen; A Pai; S W John; R S Smith; T Bottiglieri; P Bagley; J Selhub; M A Rudnicki; S J James; R Rozen Journal: Hum Mol Genet Date: 2001-03-01 Impact factor: 6.150
Authors: Alexandra S Weiner; Uljana A Boyarskikh; Elena N Voronina; Alexey E Tupikin; Olga V Korolkova; Igor V Morozov; Maxim L Filipenko Journal: Fertil Steril Date: 2013-10-23 Impact factor: 7.329