Literature DB >> 25578277

Unraveling the triterpenoid saponin biosynthesis of the African shrub Maesa lanceolata.

Tessa Moses1, Jacob Pollier2, Ahmad Faizal3, Sandra Apers4, Luc Pieters4, Johan M Thevelein5, Danny Geelen3, Alain Goossens6.   

Abstract

Maesasaponins produced by the African shrub Maesa lanceolata are oleanane-type saponins with diverse biological activities. Through a combination of transcript profiling of methyl jasmonate-elicited M. lanceolata shoot cultures, functional analysis in transgenic M. lanceolata plants and the heterologous hosts Medicago truncatula and Saccharomyces cerevisiae, we identified three maesaponin biosynthesis genes. These include a β-amyrin synthase and two cytochrome P450s, CYP716A75 and CYP87D16, which catalyze the C-28 and C-16α oxidations of β-amyrin, respectively.
Copyright © 2015 The Author. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  C-16α oxidase; C-28 oxidase; Maesa lanceolata; cytochrome P450; oxidosqualene cyclase; triterpenoid saponin

Mesh：

Substances：

Year:  2014        PMID： 25578277     DOI： 10.1016/j.molp.2014.11.004

Source DB:  PubMed          Journal:  Mol Plant        ISSN： 1674-2052            Impact factor:   13.164


  21 in total

1.  A Seed-Specific Regulator of Triterpene Saponin Biosynthesis in Medicago truncatula.

Authors:  Bianca Ribeiro; Elia Lacchini; Keylla U Bicalho; Jan Mertens; Philipp Arendt; Robin Vanden Bossche; Gabriela Calegario; Lore Gryffroy; Evi Ceulemans; Julia Buitink; Alain Goossens; Jacob Pollier
Journal:  Plant Cell       Date:  2020-04-17       Impact factor: 11.277

2.  Allylic hydroxylation of triterpenoids by a plant cytochrome P450 triggers key chemical transformations that produce a variety of bitter compounds.

Authors:  Shohei Takase; Kota Kera; Yoshiki Nagashima; Kazuto Mannen; Tsutomu Hosouchi; Sayaka Shinpo; Moeka Kawashima; Yuki Kotake; Hiroki Yamada; Yusuke Saga; Junnosuke Otaka; Hiroshi Araya; Masaaki Kotera; Hideyuki Suzuki; Tetsuo Kushiro
Journal:  J Biol Chem       Date:  2019-10-27       Impact factor: 5.157

3.  OSC2 and CYP716A14v2 catalyze the biosynthesis of triterpenoids for the cuticle of aerial organs of Artemisia annua.

Authors:  Tessa Moses; Jacob Pollier; Qian Shen; Sandra Soetaert; James Reed; Marie-Laure Erffelinck; Filip C W Van Nieuwerburgh; Robin Vanden Bossche; Anne Osbourn; Johan M Thevelein; Dieter Deforce; Kexuan Tang; Alain Goossens
Journal:  Plant Cell       Date:  2015-01-09       Impact factor: 11.277

Review 4.  Plant Metabolic Engineering Strategies for the Production of Pharmaceutical Terpenoids.

Authors:  Xu Lu; Kexuan Tang; Ping Li
Journal:  Front Plant Sci       Date:  2016-11-08       Impact factor: 5.753

Review 5.  Triterpene Structural Diversification by Plant Cytochrome P450 Enzymes.

Authors:  Sumit Ghosh
Journal:  Front Plant Sci       Date:  2017-11-09       Impact factor: 5.753

6.  A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules.

Authors:  James Reed; Michael J Stephenson; Karel Miettinen; Bastiaan Brouwer; Aymeric Leveau; Paul Brett; Rebecca J M Goss; Alain Goossens; Maria A O'Connell; Anne Osbourn
Journal:  Metab Eng       Date:  2017-07-04       Impact factor: 8.829

7.  Transcriptomic Comparison Reveals Candidate Genes for Triterpenoid Biosynthesis in Two Closely Related Ilex Species.

Authors:  Lingling Wen; Xiaoyun Yun; Xiasheng Zheng; Hui Xu; Ruoting Zhan; Weiwen Chen; Yaping Xu; Ye Chen; Jie Zhang
Journal:  Front Plant Sci       Date:  2017-04-28       Impact factor: 5.753

8.  The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis.

Authors:  Karel Miettinen; Jacob Pollier; Dieter Buyst; Philipp Arendt; René Csuk; Sven Sommerwerk; Tessa Moses; Jan Mertens; Prashant D Sonawane; Laurens Pauwels; Asaph Aharoni; José Martins; David R Nelson; Alain Goossens
Journal:  Nat Commun       Date:  2017-02-06       Impact factor: 14.919

9.  Multifunctional oxidosqualene cyclases and cytochrome P450 involved in the biosynthesis of apple fruit triterpenic acids.

Authors:  Christelle M Andre; Sylvain Legay; Amélie Deleruelle; Niels Nieuwenhuizen; Matthew Punter; Cyril Brendolise; Janine M Cooney; Marc Lateur; Jean-François Hausman; Yvan Larondelle; William A Laing
Journal:  New Phytol       Date:  2016-05-23       Impact factor: 10.151

10.  Deacetylation biocatalysis and elicitation by immobilized Penicillium canescens in Astragalus membranaceus hairy root cultures: towards the enhanced and sustainable production of astragaloside IV.

Authors:  Qing-Yan Gai; Jiao Jiao; Meng Luo; Wei Wang; Li-Ping Yao; Yu-Jie Fu
Journal:  Plant Biotechnol J       Date:  2016-09-16       Impact factor: 9.803
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