CONTEXT: We recently derived and validated a multi-biomarker-based model (ASSIST) to stratify patients with sepsis based on initial mortality risk. OBJECTIVE: The objective of this study was to compare the performance of ASSIST to interleukin-6 (IL6) and procalcitonin (PCT). METHODS: The area-under-the-receiver operating characteristic curve for predicting 28-d mortality using ASSIST was compared with that of IL6 (n = 452) and PCT (n = 235). RESULTS: The area under the curve for ASSIST was greater than that of IL6 and PCT. CONCLUSIONS: ASSIST estimated the probability of mortality more reliably than IL6 and PCT in this cohort of patients with sepsis.
CONTEXT: We recently derived and validated a multi-biomarker-based model (ASSIST) to stratify patients with sepsis based on initial mortality risk. OBJECTIVE: The objective of this study was to compare the performance of ASSIST to interleukin-6 (IL6) and procalcitonin (PCT). METHODS: The area-under-the-receiver operating characteristic curve for predicting 28-d mortality using ASSIST was compared with that of IL6 (n = 452) and PCT (n = 235). RESULTS: The area under the curve for ASSIST was greater than that of IL6 and PCT. CONCLUSIONS: ASSIST estimated the probability of mortality more reliably than IL6 and PCT in this cohort of patients with sepsis.
Authors: Daniel Molano Franco; Ingrid Arevalo-Rodriguez; Marta Roqué I Figuls; Nadia G Montero Oleas; Xavier Nuvials; Javier Zamora Journal: Cochrane Database Syst Rev Date: 2019-04-30
Authors: Valentino D'Onofrio; Dries Heylen; Murih Pusparum; Inge Grondman; Johan Vanwalleghem; Agnes Meersman; Reinoud Cartuyvels; Peter Messiaen; Leo A B Joosten; Mihai G Netea; Dirk Valkenborg; Gökhan Ertaylan; Inge C Gyssens Journal: J Intensive Care Date: 2022-03-09
Authors: Alexandre Mebazaa; Pierre François Laterre; James A Russell; Andreas Bergmann; Luciano Gattinoni; Etienne Gayat; Michael O Harhay; Oliver Hartmann; Frauke Hein; Anne Louise Kjolbye; Matthieu Legrand; Roger J Lewis; John C Marshall; Gernot Marx; Peter Radermacher; Mathias Schroedter; Paul Scigalla; Wendy Gattis Stough; Joachim Struck; Greet Van den Berghe; Mehmet Birhan Yilmaz; Derek C Angus Journal: J Intensive Care Date: 2016-03-31