Literature DB >> 25577099

Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam).

G Ruiz-Montañez1, A Burgos-Hernández2, M Calderón-Santoyo3, C M López-Saiz2, C A Velázquez-Contreras4, A Navarro-Ocaña5, J A Ragazzo-Sánchez6.   

Abstract

The present focused on the study of the antimutagenic and antiproliferative potential of pulp Jackfruit (Artocarpus heterophyllus Lam) extract, using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line M12.C3.F6 (murine B-cell lymphoma), respectively. Jackfruit pulp extract was sequentially fractionated by chromatography (RP-HPLC) and each fraction was tested for antimutagenic and antiproliferative activities. The organic extracts obtained from Jackfruit pulp reduced the number of revertants caused by aflatoxin B1 (AFB1) and proliferation of cells M12.C3.F6; a dose-response relationship was showed. Sequential RP-HPLC fractionation of the active extracts produced both antimutagenic and/or antiproliferative fractions. These results suggested that the Jackfruit contained compounds with chemoprotective properties to reduce the mutagenicity of AFB1, also proliferation of a cancer cell line.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antimutagenic; Antioxidant; Antiproliferative; Chemoprotective properties; Jackfruit pulp; RP-HPLC

Mesh：

Substances：

Year:  2014        PMID： 25577099     DOI： 10.1016/j.foodchem.2014.11.122

Source DB:  PubMed          Journal:  Food Chem        ISSN： 0308-8146            Impact factor:   7.514


  7 in total

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Journal:  Food Sci Biotechnol       Date:  2020-06-06       Impact factor: 2.391

Review 2.  Nutritional and Health Benefits of Jackfruit (Artocarpus heterophyllus Lam.): A Review.

Authors:  R A S N Ranasinghe; S D T Maduwanthi; R A U J Marapana
Journal:  Int J Food Sci       Date:  2019-01-06

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Journal:  Biomolecules       Date:  2020-02-02

Review 4.  Lesser-Consumed Tropical Fruits and Their by-Products: Phytochemical Content and Their Antioxidant and Anti-Inflammatory Potential.

Authors:  Beatriz Haydee Belmonte-Herrera; J Abraham Domínguez-Avila; Abraham Wall-Medrano; J Fernando Ayala-Zavala; Alejandra M Preciado-Saldaña; Norma J Salazar-López; Leticia X López-Martínez; Elhadi M Yahia; R Maribel Robles-Sánchez; Gustavo A González-Aguilar
Journal:  Nutrients       Date:  2022-09-05       Impact factor: 6.706

5.  Tyrosinase inhibitory activity of flavonoids from Artocarpus heterophyllous.

Authors:  Hai Xuan Nguyen; Nhan Trung Nguyen; Mai Ha Khoa Nguyen; Tho Huu Le; Truong Nhat Van Do; Tran Manh Hung; Mai Thanh Thi Nguyen
Journal:  Chem Cent J       Date:  2016-01-29       Impact factor: 4.215

6.  After In Vitro Digestion, Jackfruit Flake Affords Protection against Acrylamide-Induced Oxidative Damage.

Authors:  Daofeng Qu; Chu Liu; Mengxue Jiang; Lifang Feng; Yuewen Chen; Jianzhong Han
Journal:  Molecules       Date:  2019-09-12       Impact factor: 4.411

7.  Growth Promoting Activity of Annona muricata L. Leaf Extracts on Lactobacillus casei.

Authors:  Nimcy Noemí Meza-Gutiérrez; Paola Magallón-Servín; Rosendo Balois-Morales; Iza Fernanda Pérez-Ramírez; Graciela Guadalupe López-Guzmán; Guillermo Berumen-Varela; Pedro Ulises Bautista-Rosales
Journal:  Plants (Basel)       Date:  2022-02-22
  7 in total

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