Ryota Hase1, Yoshihito Otsuka2, Kazuki Yoshida3, Naoto Hosokawa4. 1. Department of Infectious Diseases, Kameda Medical Center. Electronic address: ryota510@hotmail.com. 2. Department of Laboratory Medicine, Kameda Medical Center. 3. Department of Epidemiology, Harvard School of Public Health. 4. Department of Infectious Diseases, Kameda Medical Center.
Abstract
OBJECTIVES: The aims of this study were to describe the epidemiological features and clinical characteristics of infective endocarditis (IE) at a tertiary-care hospital in Japan and to identify the factors associated with in-hospital mortality. METHODS: A retrospective observational study was conducted at a 925-bed tertiary-care teaching hospital in Japan. All adult patients diagnosed with definite IE between August 2000 and July 2014 according to the modified Duke criteria were included. RESULTS: A total of 180 patients (60.6% men; mean age, 69.1 years) with definite IE were included. The most common pathogen was Staphylococcus aureus (27.2%). Nine patients (5.0%) had culture-negative IE. Transthoracic and transoesophageal echocardiography were performed in 180 (100%) and 132 patients (73.3%), respectively, and vegetations were detected in 128 patients (71.1%). Surgical therapy was performed in 31 patients (17.2%). Overall, the in-hospital mortality rate was 26.1%. The independent predictors of in-hospital mortality were methicillin-resistant S. aureus (MRSA), vascular phenomena, health care-associated IE and heart failure. CONCLUSIONS: MRSA, vascular phenomena, health care-associated IE and heart failure were independent predictors of in-hospital mortality. The unique characteristics in our cohort were the very high mean age, low rate of culture-negative IE, high rate of definite IE without detected vegetations and predominance of S. aureus.
OBJECTIVES: The aims of this study were to describe the epidemiological features and clinical characteristics of infective endocarditis (IE) at a tertiary-care hospital in Japan and to identify the factors associated with in-hospital mortality. METHODS: A retrospective observational study was conducted at a 925-bed tertiary-care teaching hospital in Japan. All adult patients diagnosed with definite IE between August 2000 and July 2014 according to the modified Duke criteria were included. RESULTS: A total of 180 patients (60.6% men; mean age, 69.1 years) with definite IE were included. The most common pathogen was Staphylococcus aureus (27.2%). Nine patients (5.0%) had culture-negative IE. Transthoracic and transoesophageal echocardiography were performed in 180 (100%) and 132 patients (73.3%), respectively, and vegetations were detected in 128 patients (71.1%). Surgical therapy was performed in 31 patients (17.2%). Overall, the in-hospital mortality rate was 26.1%. The independent predictors of in-hospital mortality were methicillin-resistant S. aureus (MRSA), vascular phenomena, health care-associated IE and heart failure. CONCLUSIONS: MRSA, vascular phenomena, health care-associated IE and heart failure were independent predictors of in-hospital mortality. The unique characteristics in our cohort were the very high mean age, low rate of culture-negative IE, high rate of definite IE without detected vegetations and predominance of S. aureus.
Authors: Muhammad Zia Khan; Muhammad Bilal Munir; Muhammad U Khan; Safi U Khan; Mina M Benjamin; Sudarshan Balla Journal: Am J Cardiol Date: 2020-03-16 Impact factor: 2.778
Authors: Maria Binkiewicz-Orluk; Marcin Konopka; Katarzyna Sierakowska-Sitkiewicz; Wojciech Król; Leszek Królicki; Marek Kuch; Wojciech Braksator Journal: J Ultrason Date: 2020-03-31