Yvette P Y Leung1, Gilaad G Kaplan2, Stephanie Coward3, Divine Tanyingoh3, Bonnie J Kaplan4, David W Johnston5, Herman W Barkema6, Subrata Ghosh1, Remo Panaccione1, Cynthia H Seow7. 1. Department of Medicine, University of Calgary, Calgary, Alberta, Canada. 2. Department of Medicine, University of Calgary, Calgary, Alberta, Canada Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. 3. Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. 4. Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada. 5. Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada. 6. Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada Department of Production Animal Health, University of Calgary, Calgary, Alberta, Canada. 7. Department of Medicine, University of Calgary, Calgary, Alberta, Canada Department of Production Animal Health, University of Calgary, Calgary, Alberta, Canada cseow@ucalgary.ca.
Abstract
BACKGROUND AND AIMS: Women with inflammatory bowel disease (IBD) may be at higher risk of adverse pregnancy outcomes. This study compared perinatal outcomes in women with and without IBD. METHODS: The population-based Data Integration, Measurement, and Reporting (DIMR) administrative discharge database was used to identify women (≥18 years of age) in Alberta, Canada, with IBD who delivered a baby between 2006 and 2009 inclusive. Women without IBD were randomly sampled and matched in a 3:1 ratio to IBD cases by age at conception (±1 year). Odds ratios of gestational diabetes, preterm birth, low birth weight, cesarean section, and neonatal intensive care unit admission were calculated. RESULTS: One hundred and sixteen IBD patients were age-matched to 381 pregnant women without IBD. Gestational diabetes, preterm birth, and cesarean section were more common in women with IBD compared with controls (6.9 versus 1.8%, p = 0.03; 12.9 versus 0.3%, p < 0.0001; 43.1 versus 21.0%, p = 0.009, respectively). On multivariate analysis, women with IBD were independently more likely to have gestational diabetes (odds ratio [OR] = 4.3; 95% confidence interval [CI] 1.2-16.3), preterm birth (OR = 19.7, 95% CI 2.2-173.9), and to deliver by cesarean section (OR = 2.7, 95% CI 1.6-4.6) after adjusting for age and smoking status. CONCLUSION: Intrapartum corticosteroid use significantly increases the risk of gestational diabetes in women with IBD. Furthermore, IBD patients are at higher risk of preterm delivery and are more likely to undergo cesarean section compared with a healthy age-matched population. The finding of a higher risk of gestational diabetes is a novel finding not previously reported in the IBD literature.
BACKGROUND AND AIMS: Women with inflammatory bowel disease (IBD) may be at higher risk of adverse pregnancy outcomes. This study compared perinatal outcomes in women with and without IBD. METHODS: The population-based Data Integration, Measurement, and Reporting (DIMR) administrative discharge database was used to identify women (≥18 years of age) in Alberta, Canada, with IBD who delivered a baby between 2006 and 2009 inclusive. Women without IBD were randomly sampled and matched in a 3:1 ratio to IBD cases by age at conception (±1 year). Odds ratios of gestational diabetes, preterm birth, low birth weight, cesarean section, and neonatal intensive care unit admission were calculated. RESULTS: One hundred and sixteen IBD patients were age-matched to 381 pregnant women without IBD. Gestational diabetes, preterm birth, and cesarean section were more common in women with IBD compared with controls (6.9 versus 1.8%, p = 0.03; 12.9 versus 0.3%, p < 0.0001; 43.1 versus 21.0%, p = 0.009, respectively). On multivariate analysis, women with IBD were independently more likely to have gestational diabetes (odds ratio [OR] = 4.3; 95% confidence interval [CI] 1.2-16.3), preterm birth (OR = 19.7, 95% CI 2.2-173.9), and to deliver by cesarean section (OR = 2.7, 95% CI 1.6-4.6) after adjusting for age and smoking status. CONCLUSION: Intrapartum corticosteroid use significantly increases the risk of gestational diabetes in women with IBD. Furthermore, IBD patients are at higher risk of preterm delivery and are more likely to undergo cesarean section compared with a healthy age-matched population. The finding of a higher risk of gestational diabetes is a novel finding not previously reported in the IBD literature.
Authors: Kristin Palmsten; Matthieu Rolland; Mary F Hebert; Megan E B Clowse; Michael Schatz; Ronghui Xu; Christina D Chambers Journal: Pharmacoepidemiol Drug Saf Date: 2018-02-28 Impact factor: 2.890
Authors: Kristin Palmsten; Dani Bredesen; Meghan M JaKa; Pritika C Kumar; Jeanette Y Ziegenfuss; Elyse O Kharbanda Journal: Pharmacoepidemiol Drug Saf Date: 2020-12-22 Impact factor: 2.890