| Literature DB >> 25576159 |
Lisa J Zhang1, Yin Xiong1, Naris Nilubol1, Mei He1, Swaroop Bommareddi1, Xuguang Zhu2, Li Jia3, Zhen Xiao4, Jeong-Won Park2, Xia Xu4, Dhaval Patel1, Mark C Willingham2, Sheue-Yann Cheng2, Electron Kebebew5.
Abstract
Cancer gender disparity has been observed for a variety of human malignancies. Thyroid cancer is one such cancer with a higher incidence in women, but more aggressive disease in men. There is scant evidence on the role of sex hormones on cancer initiation/progression. Using a transgenic mouse model of follicular thyroid cancer (FTC), we found castration led to lower rates of cancer in females and less advanced cancer in males. Mechanistically, less advanced cancer in castrated males was due to increased expression of tumor suppressor (Glipr1, Sfrp1) and immune-regulatory genes and higher tumor infiltration with M1 macrophages and CD8 cells. Functional study showed that GLIPR1 reduced cell growth and increased chemokine secretion (Ccl5) that activates immune cells. Our data demonstrate that testosterone regulates thyroid cancer progression by reducing tumor suppressor gene expression and tumor immunity. Published by Oxford University Press 2015.Entities:
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Year: 2015 PMID： 25576159 PMCID： PMC4392603 DOI： 10.1093/carcin/bgv001
Source DB: PubMed Journal: Carcinogenesis ISSN： 0143-3334 Impact factor: 4.944