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Literature DB >> 25575696

The role of IL-21 in immunity and cancer.

Matthew R Davis¹, Ziwen Zhu², Dwayne M Hansen¹, Qian Bai², Yujiang Fang³.

Abstract

Interleukin-21 (IL-21), produced predominantly by CD4+ T cells and natural killer T (NKT) cells, is a newly discovered member of the common γ-chain family of cytokines. It has been implicated in many immunological processes and has been linked to autoimmune diseases, allergies and other inflammatory diseases. In recent years, the role for IL-21 in the pathogenesis of cancer has also been extensively studied. In this review, we will discuss recent advances concerning the role of IL-21 in immunological processes and the pathogenesis of cancer.

Entities: Disease Gene

Keywords: Cancer; IL-21; Immune response

Mesh：

Substances：

Year: 2015 PMID： 25575696 DOI： 10.1016/j.canlet.2014.12.047

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

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Cited

46 in total

1. Highly efficient IL-21 and feeder cell-driven ex vivo expansion of human NK cells with therapeutic activity in a xenograft mouse model of melanoma.

Authors: Markus Granzin; Ana Stojanovic; Matthias Miller; Richard Childs; Volker Huppert; Adelheid Cerwenka
Journal: Oncoimmunology Date: 2016-08-05 Impact factor: 8.110

2. Epigenetic Changes in Alveolar Type II Lung Cells of A/J Mice Following Intranasal Treatment with Lipopolysaccharide.

Authors: Christopher L Seiler; Jung Min Song; Jenna Fernandez; Juan E Abrahante; Thomas J Y Kono; Yue Chen; Yanan Ren; Fekadu Kassie; Natalia Y Tretyakova
Journal: Chem Res Toxicol Date: 2019-04-16 Impact factor: 3.739

3. Mechanism involved in interleukin-21-induced phagocytosis in human monocytes and macrophages.

Authors: F Vallières; D Girard
Journal: Clin Exp Immunol Date: 2016-11-22 Impact factor: 4.330

Review 4. Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy.

Authors: Elena García-Martínez; Melody Smith; Aitziber Buqué; Fernando Aranda; Francisco Ayala de la Peña; Alejandra Ivars; Manuel Sanchez Cánovas; Ma Angeles Vicente Conesa; Jitka Fucikova; Radek Spisek; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal: Oncoimmunology Date: 2018-02-15 Impact factor: 8.110

5. Distribution of circulating follicular helper T cells and expression of interleukin-21 and chemokine C-X-C ligand 13 in gastric cancer.

Authors: Xinying Meng; Xinjuan Yu; Quanjiang Dong; Xiaona Xu; Jinghua Li; Qianqian Xu; Jian Ma; Changhong Zhou
Journal: Oncol Lett Date: 2018-07-10 Impact factor: 2.967

10. Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.

Authors: R Xing; Y Jin; L Sun; L Yang; C Li; Z Li; X Liu; J Zhao
Journal: Clin Exp Immunol Date: 2016-02-15 Impact factor: 4.330

The role of IL-21 in immunity and cancer.

1. Highly efficient IL-21 and feeder cell-driven ex vivo expansion of human NK cells with therapeutic activity in a xenograft mouse model of melanoma.

2. Epigenetic Changes in Alveolar Type II Lung Cells of A/J Mice Following Intranasal Treatment with Lipopolysaccharide.

3. Mechanism involved in interleukin-21-induced phagocytosis in human monocytes and macrophages.

Review 4. Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy.

5. Distribution of circulating follicular helper T cells and expression of interleukin-21 and chemokine C-X-C ligand 13 in gastric cancer.

6. The novel role of IL-37 in prostate cancer: evidence as a promising radiosensitizer.

Review 7. Emerging nanotechnologies for cancer immunotherapy.

8. Germline mutations and blood malignancy (Review).

9. Advances of the interleukin-21 signaling pathway in immunity and angiogenesis.

10. Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.