Jingwen Chen1, Muyan Li2, Qun Lv3, Guoli Chen4, Yong Li1, Shaojun Li1, Yuhuan Mo1, Shiyan Ou1, Zongxiang Yuan1, Mingli Huang1, Yueming Jiang5. 1. Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. 2. Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China. 3. Maternity and Child Care Health Hospital of Guangxi, Nanning, Guangxi, China. 4. Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. 5. Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. Electronic address: ymjianggxmu@163.com.
Abstract
OBJECTIVE: Our study aimed to assess the distribution of blood lead level and its relationship to essential elements in preschool children in an urban area of China. DESIGN AND METHODS: A total of 6741 children aged 0- to 6-year-old were recruited. Levels of lead, zinc, copper, iron, calcium, and magnesium in whole blood samples were determined using atomic absorption spectrometry. RESULTS: The mean blood lead level (BLL) and the prevalence of BLL≥10μg/dl (5.26±4.08μg/dl and 6.84%, respectively) increased with age gradually, and there was a gender-difference for blood lead, copper, zinc and iron levels. Compared with the group of children who had BLLs<5μg/dl, the groups of 5≤BLLs<10μg/dl and 10≤BLLs<15μg/dl showed higher blood zinc, iron and magnesium levels, and a lower blood calcium level. A positive correlation of lead with zinc, iron and magnesium, and a negative correlation of lead with calcium were found in the group of children with BLL<5μg/dl. CONCLUSION: Age- and gender-differences were found when assessing the BLL and intoxication prevalence in preschool children. Metabolic disorder of essential elements was found even with a low level of lead exposure.
OBJECTIVE: Our study aimed to assess the distribution of blood lead level and its relationship to essential elements in preschool children in an urban area of China. DESIGN AND METHODS: A total of 6741 children aged 0- to 6-year-old were recruited. Levels of lead, zinc, copper, iron, calcium, and magnesium in whole blood samples were determined using atomic absorption spectrometry. RESULTS: The mean blood lead level (BLL) and the prevalence of BLL≥10μg/dl (5.26±4.08μg/dl and 6.84%, respectively) increased with age gradually, and there was a gender-difference for blood lead, copper, zinc and iron levels. Compared with the group of children who had BLLs<5μg/dl, the groups of 5≤BLLs<10μg/dl and 10≤BLLs<15μg/dl showed higher blood zinc, iron and magnesium levels, and a lower blood calcium level. A positive correlation of lead with zinc, iron and magnesium, and a negative correlation of lead with calcium were found in the group of children with BLL<5μg/dl. CONCLUSION: Age- and gender-differences were found when assessing the BLL and intoxication prevalence in preschool children. Metabolic disorder of essential elements was found even with a low level of lead exposure.
Authors: Qian Luo; Honglong Zhang; Haiping Wang; Li Ma; Min Huang; Jingping Niu; Bin Luo; Jun Yan; Xun Li Journal: Biol Trace Elem Res Date: 2021-10-28 Impact factor: 4.081
Authors: Shan Tan; Yang Yang; Zhiheng Chen; Lingling Zhao; Zuocheng Yang; Hongmei Dai; Wei He; Mei Jiang; Yanhua Yao; Ke Huang; Liu Li; Pengfei Zhu; Shasha Xu; Mingyi Zhao; Minghua Yang Journal: Front Public Health Date: 2022-04-18