R B T Lim1, C Chen2, N Naidoo2, G Gay2, W E Tang3, D Seah3, R Chen4, N C Tan5, J Lee2, E S Tai2, K S Chia2, W Y Lim2. 1. Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, #10-01, Singapore city 117549, Singapore. Electronic address: raymondlim1302@gmail.com. 2. Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, #10-01, Singapore city 117549, Singapore. 3. National Healthcare Group Polyclinics, Singapore City, Singapore. 4. Changi General Hospital, Singapore City, Singapore. 5. Singhealth Polyclinics, Singapore City, Singapore.
Abstract
AIM: The study investigated the relationship of general (body mass index [BMI]) and central (waist circumference [WC]; waist-hip ratio [WHipR]; waist-height ratio [WHeightR]) adiposity with all-cause and cardiovascular disease (CVD)-related mortality in an Asian population with diabetes. METHODS: A total of 13,278 participants with type 2 diabetes mellitus (T2DM) recruited from public-sector primary-care and specialist outpatients clinics in Singapore were followed-up for a median duration of 2.9 years, during which time there were 524 deaths. Cox proportional-hazards regression and competing-risk models were used to obtain hazard ratios (HRs) for anthropometric variables of all-cause and CVD-related mortality. RESULTS: After adjusting for BMI, the highest quintiles of WC, WHipR and WHeightR were all positively associated with mortality compared with the lowest quintiles, with WHeightR exhibiting the largest effect sizes [all-cause mortality HR: 2.13, 95% confidence interval (CI): 1.33-3.42; CVD-related mortality HR: 3.42, 95% CI: 1.62-7.19]. Being overweight but not obese (BMI:≥23.0 but<27.5kg/m(2)) was associated with a decreased risk of CVD-related mortality in those aged≥65 years (HR: 0.47, 95% CI: 0.29-0.75), but not in those aged<65 years (HR: 1.11, 95% CI: 0.49-2.50). CONCLUSION: Overweight, but not obesity, was associated with a reduction in risk of mortality. This was seen in T2DM patients aged≥65 years, but not in those younger than this. At the same BMI, having higher central-obesity indices such as WC, WHipR and WHeightR also increased the risk of mortality.
AIM: The study investigated the relationship of general (body mass index [BMI]) and central (waist circumference [WC]; waist-hip ratio [WHipR]; waist-height ratio [WHeightR]) adiposity with all-cause and cardiovascular disease (CVD)-related mortality in an Asian population with diabetes. METHODS: A total of 13,278 participants with type 2 diabetes mellitus (T2DM) recruited from public-sector primary-care and specialist outpatients clinics in Singapore were followed-up for a median duration of 2.9 years, during which time there were 524 deaths. Cox proportional-hazards regression and competing-risk models were used to obtain hazard ratios (HRs) for anthropometric variables of all-cause and CVD-related mortality. RESULTS: After adjusting for BMI, the highest quintiles of WC, WHipR and WHeightR were all positively associated with mortality compared with the lowest quintiles, with WHeightR exhibiting the largest effect sizes [all-cause mortality HR: 2.13, 95% confidence interval (CI): 1.33-3.42; CVD-related mortality HR: 3.42, 95% CI: 1.62-7.19]. Being overweight but not obese (BMI:≥23.0 but<27.5kg/m(2)) was associated with a decreased risk of CVD-related mortality in those aged≥65 years (HR: 0.47, 95% CI: 0.29-0.75), but not in those aged<65 years (HR: 1.11, 95% CI: 0.49-2.50). CONCLUSION: Overweight, but not obesity, was associated with a reduction in risk of mortality. This was seen in T2DM patients aged≥65 years, but not in those younger than this. At the same BMI, having higher central-obesity indices such as WC, WHipR and WHeightR also increased the risk of mortality.
Authors: Raymond Boon Tar Lim; Wei Keong Wee; Wei Chek For; Jayalakshmy Aarthi Ananthanarayanan; Ying Hua Soh; Lynette Mei Lim Goh; Dede Kam Tyng Tham; Mee Lian Wong Journal: Nutrients Date: 2019-05-06 Impact factor: 5.717
Authors: Raymond Boon Tar Lim; Wei Keong Wee; Wei Chek For; Jayalakshmy Aarthi Ananthanarayanan; Ying Hua Soh; Lynette Mei Lim Goh; Dede Kam Tyng Tham; Mee Lian Wong Journal: BMC Public Health Date: 2020-01-02 Impact factor: 3.295
Authors: Nasser M Al-Daghri; Omar S Al-Attas; Kaiser Wani; Abdullah M Alnaami; Shaun Sabico; Abdulrahman Al-Ajlan; George P Chrousos; Majed S Alokail Journal: Cardiovasc Diabetol Date: 2015-08-07 Impact factor: 9.951