Tyree H Kiser1, R William Vandivier. 1. aDepartment of Clinical Pharmacy bDepartment of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, COPD Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Abstract
PURPOSE OF REVIEW: Severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are significant events that result in substantial morbidity and mortality. Antibiotic therapy and systemic corticosteroids are important treatments for patients with severe AECOPD. The objective of this review is to summarize the most recent evidence concerning antibiotic and corticosteroid therapy, with a focused evaluation on the contribution of antibiotic type and corticosteroid dosage on patient outcomes. RECENT FINDINGS: Macrolides should be considered the antibiotic of choice for prevention of AECOPD in patients who qualify for therapy. Macrolides, fluoroquinolones, and beta-lactams are all reasonable treatment options for severe AECOPD and the decision to use one over the other should be based upon patient characteristics and institutional or regional antimicrobial susceptibility patterns. The best available evidence now suggests that higher-dose corticosteroids are not superior to treatment with lower-dose corticosteroids in patients with severe AECOPD. Additionally, longer durations of systemic corticosteroid therapy do not improve clinical outcomes. SUMMARY: Several antibiotic options are efficacious in the management of severe AECOPD and drug selection should be patient-specific. Recent studies suggest that lower dosages and shorter durations of corticosteroid treatment may be prudent.
PURPOSE OF REVIEW: Severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are significant events that result in substantial morbidity and mortality. Antibiotic therapy and systemic corticosteroids are important treatments for patients with severe AECOPD. The objective of this review is to summarize the most recent evidence concerning antibiotic and corticosteroid therapy, with a focused evaluation on the contribution of antibiotic type and corticosteroid dosage on patient outcomes. RECENT FINDINGS:Macrolides should be considered the antibiotic of choice for prevention of AECOPD in patients who qualify for therapy. Macrolides, fluoroquinolones, and beta-lactams are all reasonable treatment options for severe AECOPD and the decision to use one over the other should be based upon patient characteristics and institutional or regional antimicrobial susceptibility patterns. The best available evidence now suggests that higher-dose corticosteroids are not superior to treatment with lower-dose corticosteroids in patients with severe AECOPD. Additionally, longer durations of systemic corticosteroid therapy do not improve clinical outcomes. SUMMARY: Several antibiotic options are efficacious in the management of severe AECOPD and drug selection should be patient-specific. Recent studies suggest that lower dosages and shorter durations of corticosteroid treatment may be prudent.